Assessment of pulmonary 18F-FDG-PET uptake and cytokine profiles in non-small cell lung cancer patients treated with radiotherapy and erlotinib
In: Clinical and Translational Radiation Oncology, Jg. 4 (2017), Heft C, S. 57-63
Online
academicJournal
Zugriff:
Purpose: To investigate effects of radiotherapy (RT) and erlotinib on pulmonary glucose uptake using 2-deoxy-2-(18F)fluoro-D-glucose (18F-FDG) positron emission tomography (PET) during and after treatment of non-small cell lung cancer (NSCLC) and to identify associations between serum cytokine levels and lung glucose uptake. Material and methods: Twenty-seven patients with advanced NSCLC, receiving RT alone or concomitant RT and erlotinib therapy, were examined by 18F-FDG PET before, during, and after treatment. A total of 57 18F-FDG PET scans were analyzed. Pulmonary 18F-FDG uptake and radiotherapy dose mapping were used to acquire dose-response curves for each patient, where subsequent linear regression gave a glucose uptake level in the un-irradiated parts of the lungs (SUV0) and a response slope (ΔSUV). Serum cytokine levels at corresponding time points were assessed using a multiplex bioassay. Correlations between the most robust cytokines and lung 18F-FDG dose response parameters were further investigated. Results: From the dose response analysis, SUV0 at post-therapy was significantly higher (P
| Titel: |
Assessment of pulmonary 18F-FDG-PET uptake and cytokine profiles in non-small cell lung cancer patients treated with radiotherapy and erlotinib
|
|---|---|
| Autor/in / Beteiligte Person: | Abravan, Azadeh ; Hanne Astrid Eide ; Ingerid Skjei Knudtsen ; Ayca Muftuler Løndalen ; Helland, Åslaug ; Malinen, Eirik |
| Link: | |
| Zeitschrift: | Clinical and Translational Radiation Oncology, Jg. 4 (2017), Heft C, S. 57-63 |
| Veröffentlichung: | Elsevier, 2017 |
| Medientyp: | academicJournal |
| ISSN: | 2405-6308 (print) |
| DOI: | 10.1016/j.ctro.2017.04.002 |
| Schlagwort: |
|
| Sonstiges: |
|