Galanin-expression and galanin-dependent sensory neurons are not required for itch
In: Molecular Pain, Jg. 8 (2012-12-01), Heft 1, S. 87-87
Online
academicJournal
Zugriff:
Abstract Background Galanin is a key modulator of nociception, and it is also required for the developmental survival of a subset of C-fibre sensory neurons which are critical to the mediation of neuropathic and inflammatory pain. However, the potential modulatory roles played by galanin, or the galanin-dependent neurons, in pruritoceptive mechanisms underlying the sensation of itch have not been investigated. Findings Here we report that mice carrying a loss-of-function mutation in the galanin gene (Gal-KO) show no differences in spontaneous behavioural itch responses compared to wild-type (WT) controls. Similarly, the responses to a range of pruritogens are not significantly different between the two genotypes. Conclusions These results suggest that neither galanin expression, nor the galanin-dependent subpopulation of sensory neurons is required for itch-related behaviours.
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Galanin-expression and galanin-dependent sensory neurons are not required for itch
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Autor/in / Beteiligte Person: | Holmes Fiona, E ; Penny, Vanderplank ; David, Wynick |
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Zeitschrift: | Molecular Pain, Jg. 8 (2012-12-01), Heft 1, S. 87-87 |
Veröffentlichung: | SAGE Publishing, 2012 |
Medientyp: | academicJournal |
ISSN: | 1744-8069 (print) |
DOI: | 10.1186/1744-8069-8-87 |
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