Mechanism of Borrelia immune evasion by FhbA-related proteins.
In: PLoS Pathogens, Jg. 18 (2022-03-01), Heft 3, S. e1010338
Online
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Zugriff:
Immune evasion facilitates survival of Borrelia, leading to infections like relapsing fever and Lyme disease. Important mechanism for complement evasion is acquisition of the main host complement inhibitor, factor H (FH). By determining the 2.2 Å crystal structure of Factor H binding protein A (FhbA) from Borrelia hermsii in complex with FH domains 19-20, combined with extensive mutagenesis, we identified the structural mechanism by which B. hermsii utilizes FhbA in immune evasion. Moreover, structure-guided sequence database analysis identified a new family of FhbA-related immune evasion molecules from Lyme disease and relapsing fever Borrelia. Conserved FH-binding mechanism within the FhbA-family was verified by analysis of a novel FH-binding protein from B. duttonii. By sequence analysis, we were able to group FH-binding proteins of Borrelia into four distinct phyletic types and identified novel putative FH-binding proteins. The conserved FH-binding mechanism of the FhbA-related proteins could aid in developing new approaches to inhibit virulence and complement resistance in Borrelia.
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Mechanism of Borrelia immune evasion by FhbA-related proteins.
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Autor/in / Beteiligte Person: | Kogan, Konstantin ; Haapasalo, Karita ; Kotila, Tommi ; Moore, Robin ; Lappalainen, Pekka ; Goldman, Adrian ; Meri, Taru |
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Zeitschrift: | PLoS Pathogens, Jg. 18 (2022-03-01), Heft 3, S. e1010338 |
Veröffentlichung: | Public Library of Science (PLoS), 2022 |
Medientyp: | academicJournal |
ISSN: | 1553-7366 (print) ; 1553-7374 (print) |
DOI: | 10.1371/journal.ppat.1010338 |
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