Gene Expression and Cardiometabolic Phenotypes of Vitamin D-Deficient Overweight and Obese Black Children
In: Nutrients, Jg. 11 (2019-08-01), Heft 9, S. 2016-2016
Online
academicJournal
Zugriff:
Associations between whole blood transcriptome and clinical phenotypes in vitamin D-deficient overweight and obese children can provide insight into the biological effects of vitamin D and obesity. We determined differentially expressed genes (DEGs) in relation to body mass index (BMI) in vitamin D-deficient black children with a BMI ≥ 85th percentile and ascertained the cardiometabolic phenotypes associated with the DEGs. We examined whole-blood transcriptome gene expression by RNA sequencing and cardiometabolic profiling in 41, 10- to 18-year-old children. We found 296 DEGs in association with BMI after adjusting for age, race, sex, and pubertal status. Cardiometabolic phenotypes associated with the BMI-related DEGs, after adjusting for age, sex, pubertal status, and %total body fat, were (i) flow-mediated dilation (marker of endothelial function), (ii) c-reactive protein (marker of inflammation), and (iii) leptin (adipocytokine). Canonical pathways of relevance for childhood obesity and its phenotypes that were significantly associated with the BMI-related DEGs affected immune cell function/inflammation, vascular health, metabolic function, and cell survival/death; several immune and inflammatory pathways overlapped across the three phenotypes. We have identified transcriptome-based biomarkers associated with BMI in vitamin D-deficient, overweight and obese black children. Modulating effects of vitamin D supplementation on these biomarkers and their related phenotypes need further exploration.
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Gene Expression and Cardiometabolic Phenotypes of Vitamin D-Deficient Overweight and Obese Black Children
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Autor/in / Beteiligte Person: | Rajakumar, Kumaravel ; Yan, Qi ; Khalid, Arshad T. ; Feingold, Eleanor ; Vallejo, Abbe N. ; F. Yesim Demirci ; M. Ilyas Kamboh |
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Zeitschrift: | Nutrients, Jg. 11 (2019-08-01), Heft 9, S. 2016-2016 |
Veröffentlichung: | MDPI AG, 2019 |
Medientyp: | academicJournal |
ISSN: | 2072-6643 (print) |
DOI: | 10.3390/nu11092016 |
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