Early Administration of Protein in Critically Ill Patients: A Retrospective Cohort Study
In: Nutrients, Jg. 11 (2019), Heft 1, S. 106-106
Online
academicJournal
Zugriff:
It is currently uncertain whether early administration of protein improves patient outcomes. We examined mortality rates of critically ill patients receiving early compared to late protein administration. This was a retrospective cohort study of mixed ICU patients receiving enteral or parenteral nutritional support. Patients receiving >0.7 g/kg/d protein within the first 3 days were considered the early protein group and those receiving less were considered the late protein group. The latter were subdivided into late-low group (LL) who received a low protein intake (0.7 g/kg/d) of protein following their first 3 days of admission. The outcome measure was all-cause mortality 60 days after admission. Of the 2253 patients included in the study, 371 (36%) in the early group, and 517 (43%) in the late-high group had died (p < 0.001 for difference). In multivariable Cox regression analysis, while controlling for confounders, early protein administration was associated with increased survival (HR 0.83, 95% CI 0.71–0.97, p = 0.017). Administration of protein early in the course of critical illness appears to be associated with improved survival in a mixed ICU population, even after adjusting for confounding variables.
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Early Administration of Protein in Critically Ill Patients: A Retrospective Cohort Study
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Autor/in / Beteiligte Person: | Bendavid, Itai ; Zusman, Oren ; Kagan, Ilya ; Theilla, Miriam ; Cohen, Jonathan ; Singer, Pierre |
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Zeitschrift: | Nutrients, Jg. 11 (2019), Heft 1, S. 106-106 |
Veröffentlichung: | MDPI AG, 2019 |
Medientyp: | academicJournal |
ISSN: | 2072-6643 (print) |
DOI: | 10.3390/nu11010106 |
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