17q21 variants modify the association between early respiratory infections and asthma.
In: ISSN: 0903-1936, 2010
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academicJournal
Zugriff:
International audience ; Single nucleotide polymorphisms (SNPs) at chromosome 17q21 confer an increased risk of early-onset asthma. The objective was to study whether 17q21 SNPs modify associations between early respiratory infections and asthma. Association analysis was conducted in 499 children (268 with asthma, median age 11 yrs) from the Epidemiological Study on the Genetics and Environment of Asthma (EGEA). The 12-yr follow-up data were used to assess persistent or remittent asthma in young adulthood. Respiratory infection before 2 yrs of age was assessed retrospectively. For the 12 17q21 SNPs studied, the odds ratios (OR) for association between infection and early-onset asthma (age at onset
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17q21 variants modify the association between early respiratory infections and asthma.
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| Autor/in / Beteiligte Person: | Smit, Lidwien, A.M. ; Bouzigon, Emmanuelle ; Pin, Isabelle ; Siroux, Valérie ; Monier, F. ; Aschard, Hugues ; Bousquet, Jean ; Gormand, Frédéric ; Just, Jocelyne ; Le Moual, Nicole ; Nadif, Rachel ; Scheinmann, Pierre ; Vervloet, Daniel ; Lathrop, Mark ; Demenais, Florence ; Kauffmann, Francine ; Division of Environmental Epidemiology ; Universiteit Utrecht / Utrecht University Utrecht -Institute of Risk Assessment Sciences ; Recherche en épidémiologie et biostatistique ; Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM) ; Centre d'Etude du Polymorphisme Humain (CEPH) ; Université Paris Diderot - Paris 7 (UPD7)-Institut Universitaire d'Hématologie (IUH) ; Université Paris Diderot - Paris 7 (UPD7)-Fondation Jean Dausset ; Variabilité Génétique et Maladies Humaines (U946) ; Institut Universitaire d'Hématologie (IUH) ; Université Paris Diderot - Paris 7 (UPD7)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM) ; Département de pédiatrie ; Centre Hospitalier Universitaire CHU Grenoble (CHUGA)-Hôpital Michallon ; Institut d'oncologie/développement Albert Bonniot de Grenoble (INSERM U823) ; Université Joseph Fourier - Grenoble 1 (UJF)-Centre Hospitalier Universitaire CHU Grenoble (CHUGA)-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM) ; Département pneumologie et addictologie Montpellier ; Hôpital Arnaud de Villeneuve CHRU Montpellier ; Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier)-Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier) ; Service de pneumologie Centre Hospitalier Lyon Sud -, HCL ; Centre Hospitalier Lyon Sud CHU - HCL (CHLS) ; Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL) ; CHU Trousseau, APHP ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU) ; Service de Pneumologie Allergologie CHU Necker ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Necker - Enfants Malades AP-HP ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP) ; Service de Pneumo-Allergologie ; Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital Sainte-Marguerite CHU - APHM (Hôpitaux Sud ) ; Centre National de Génotypage (CNG) ; Commissariat à l'énergie atomique et aux énergies alternatives (CEA) ; Supported by the French Ministry of Higher Education and Research, University Paris Diderot-Paris 7, grants from the French Agency for Environmental and Occupational Health Safety (grant AFSSET-APR-SE-2004), the French National Agency for Research (grants ANR 05-SEST-020-02/05-9-97 and ANR 06-CEBS), Merck Sharp & Dohme (MSD), Hospital program of clinical research (PHRC)-Paris, and GABRIEL, a multidisciplinary study to identify the genetic and environmental causes of asthma in the European Community (contract n° 01896 under the Integrated Programme LSH-2004-1.2.5-1 Post genomic approaches to understand the molecular bias of asthma aiming at a preventive or therapeutic control). Lidwien Smit is supported by a European Academy of Allergology and Clinical Immunology- Global Allergy and Asthma European Network (EAACI-GA2LEN) exchange fellowship award. ; ANR-05-SEST-0020,ANR-05-SEST-0020,Facteurs environnementaux et interactions gène environnnement dans l'asthme et l'allergie(2005) |
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| Zeitschrift: | ISSN: 0903-1936, 2010 |
| Veröffentlichung: | HAL CCSD ; European Respiratory Society, 2010 |
| Medientyp: | academicJournal |
| DOI: | 10.1183/09031936.00154509 |
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