Evaluation of acoustic signal features in children with community-acquired pneumonia and pneumonia caused by the SARS-CoV-2 virus using the new acoustic monitoring device 'Trembita-Corona'

Early diagnosing pneumonia caused by the SARS-CoV-2 virus is an urgent problem today. The diagnosis of pneumonia caused by the SARS-CoV-2 virus is difficult, which is why it is promising to use acoustic monitoring to speed up the diagnosis and start of therapy. Aim: to determine the features of acoustic diagnostics of children with pneumonia caused by the SARS-CoV-2 virus using the "Trembita-Corona" acoustic monitoring device to correct and supplement traditional diagnostic methods. That is why respiratory acoustics is currently a promising scientific direction. We, pediatric specialists from Ukraine and leading specialists of the National Aviation University (Ukraine), have developed an experimental sample of the "Trembita-Corona" acoustic monitoring device. This device is used to diagnose breathing sounds. A patent protects the main constructive technical solutions of this device. Methods. We studied 230 patients aged 1 month to 18 years. The children were divided into 3 groups: 1 group – 100 patients with САР (the PCR test for the determination of the SARS-CoV-2 virus is negative), 2 group -100 healthy children(the PCR test for the determination of the SARS-CoV-2 virus is negative), 3 group - 30 children with pneumonia caused by the SARS-CoV-2 virus the PCR test for the determination of the SARS-CoV-2 virus is positive). The study complied with the international principles of GCP, GLP for clinical research. The protocol was approved at the meeting of the Commission on Bioethical Expertise at the National Medical University, named after O.O. Bogomolets. Mathematical processing was performed on specialized software developed in the Python language in the Google Codelabs environment. Further statistical processing of the obtained results was performed in specialized programs Medstart, EZR (R-Statistics) and "Matlab". Results. We use the "Trembita-Corona" acoustic monitoring device to analyze sounds at different octaves. In each of the 11 octaves using the "Trembita-Corona" acoustic monitoring device, we ...