A biologically informed polygenic score of neuronal plasticity moderates the association between cognitive aptitudes and cortical thickness in adolescents
In: ISSN: 1878-9293, 2023
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International audience ; Although many studies of the adolescent brain identified positive associations between cognitive abilities and cortical thickness, little is known about mechanisms underlying such brain-behavior relationships. With experience-induced plasticity playing an important role in shaping the cerebral cortex throughout life, it is likely that some of the inter-individual variations in cortical thickness could be explained by genetic variations in relevant molecular processes, as indexed by a polygenic score of neuronal plasticity (PGS-NP). Here, we studied associations between PGS-NP, cognitive abilities, and thickness of the cerebral cortex, estimated from magnetic resonance images, in the Saguenay Youth Study (SYS, 533 females, 496 males: age=15.0 ± 1.8 years of age; cross-sectional), and the IMAGEN Study (566 females, 556 males; between 14 and 19 years; longitudinal). Using Gene Ontology, we first identified 199 genes implicated in neuronal plasticity, which mapped to 155,600 single nucleotide polymorphisms (SNPs). Second, we estimated their effect sizes from an educational attainment meta-GWAS to build a PGS-NP. Third, we examined a possible moderating role of PGS-NP in the relationship between performance intelligence quotient (PIQ), and its subtests, and the thickness of 34 cortical regions. In SYS, we observed a significant interaction between PGS-NP and object assembly vis-à-vis thickness in male adolescents (p = 0.026). A median-split analysis showed that, in males with a 'high' PGS-NP, stronger associations between object assembly and thickness were found in regions with larger age-related changes in thickness (r = 0.55, p = 0.00075). Although the interaction between PIQ and PGS-NP was non-significant (p = 0.064), we performed a similar median-split analysis. Again, in the high PGS-NP males, positive associations between PIQ and thickness were observed in regions with larger age-related changes in thickness (r = 0.40, p = 0.018). In the IMAGEN cohort, we did not replicate the first set ...
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A biologically informed polygenic score of neuronal plasticity moderates the association between cognitive aptitudes and cortical thickness in adolescents
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| Autor/in / Beteiligte Person: | Navarri, Xavier ; Vosberg, Daniel ; Shin, Jean ; Richer, Louis ; Leonard, Gabriel ; Pike, G Bruce ; Banaschewski, Tobias ; Bokde, Arun ; Desrivières, Sylvane ; Flor, Herta ; Grigis, Antoine ; Garavan, Hugh ; Gowland, Penny ; Heinz, Andreas ; Brühl, Rüdiger ; Martinot, Jean-Luc ; Martinot, Marie-Laure Paillère ; Artiges, Eric ; Nees, Frauke ; Orfanos, Dimitri Papadopoulos ; Poustka, Luise ; Hohmann, Sarah ; Fröhner, Juliane ; Smolka, Michael ; Vaidya, Nilakshi ; Walter, Henrik ; Whelan, Robert ; Schumann, Gunter ; Pausova, Zdenka ; Paus, Tomáš ; Université de Montréal (UdeM) ; University of Toronto ; Université du Québec à Chicoutimi (UQAC) ; McGill University = Université McGill Montréal, Canada ; University of Calgary ; Universität Heidelberg Heidelberg = Heidelberg University ; Trinity College Dublin ; King‘s College London ; Service NEUROSPIN (NEUROSPIN) ; Université Paris-Saclay-Institut des Sciences du Vivant Frédéric JOLIOT (JOLIOT) ; Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA) ; University of Vermont Burlington ; University of Nottingham, UK (UON) ; Humboldt-Universität zu Berlin = Humboldt University of Berlin = Université Humboldt de Berlin (HU Berlin) ; Physikalisch-Technische Bundesanstalt Berlin (PTB) ; CB - Centre Borelli - UMR 9010 (CB) ; Service de Santé des Armées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Ecole Normale Supérieure Paris-Saclay (ENS Paris Saclay)-Université Paris Cité (UPCité) ; Trajectoires développementales en psychiatrie : mesures et modélisations (ERL Inserm U1299 ) ; Service de Santé des Armées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Ecole Normale Supérieure Paris-Saclay (ENS Paris Saclay)-Université Paris Cité (UPCité)-Service de Santé des Armées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Ecole Normale Supérieure Paris-Saclay (ENS Paris Saclay)-Université Paris Cité (UPCité) ; Institute of Pathology - University Medical Centre Göttingen ; Technische Universität Dresden = Dresden University of Technology (TU Dresden) ; Charité - UniversitätsMedizin = Charité - University Hospital Berlin ; Fudan University Shanghai ; Centre de recherche du CHU Sainte-Justine / Research Center of the Sainte-Justine University Hospital Montreal, Canada ; Université de Montréal (UdeM)-CHU Sainte Justine Montréal ; ANR-12-SAMA-0004,ADODEP,Dépression à l'Adolescence: Structure cérébrale et myélinisation(2012) ; ANR-18-NEUR-0002,ADORe,TARGETING ADOLESCENT NEUROCOGNITIVE PROCESSES IN DEPRESSION TO PROMOTE INTERVENTION RESPONSE(2018) ; European Project: 39513,IMAGEN ; European Project: 695313,EXCELLENT SCIENCE - European Research Council (ERC),STRATIFY(2016) ; European Project: 785907,H2020,HBP SGA2(2018) ; European Project: 945539,H2020,H2020-SGA-FETFLAG-HBP-2019,HBP SGA3(2020) ; European Project: 101057429,EnvironMENTAL |
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| Zeitschrift: | ISSN: 1878-9293, 2023 |
| Veröffentlichung: | HAL CCSD ; Elsevier, 2023 |
| Medientyp: | academicJournal |
| DOI: | 10.1016/j.dcn.2023.101232 |
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