Human kidney-derived hematopoietic stem cells can support long-term multilineage hematopoiesis
In: ISSN: 0085-2538, 2023
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academicJournal
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International audience ; Long-term multilineage hematopoietic donor chimerism occurs sporadically in patients who receive a transplanted solid organ enriched in lymphoid tissues such as the intestine or liver. There is currently no evidence for the presence of kidney-resident hematopoietic stem cells in any mammal species. Graft-versus-host-reactive donor T cells promote engraftment of graft-derived hematopoietic stem cells by making space in the bone marrow. Here, we report full (over 99%) multilineage, donor-derived hematopoietic chimerism in a pediatric kidney transplant recipient with syndromic combined immune deficiency that leads to transplant tolerance. Interestingly, we found that the human kidney-derived hematopoietic stem cells took up long-term residence in the recipient's bone marrow and gradually replaced their host counterparts, leading to blood type conversion and full donor chimerism of both lymphoid and myeloid lineages. Thus, our findings highlight the existence of human kidney-derived hematopoietic stem cells with a self-renewal ability able to support multilineage hematopoiesis.
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Human kidney-derived hematopoietic stem cells can support long-term multilineage hematopoiesis
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| Autor/in / Beteiligte Person: | Sobrino, Steicy ; Abdo, Chrystelle ; Neven, Bénédicte ; Denis, Adeline ; Gouge-Biebuyck, Nathalie ; Clave, Emmanuel ; Charbonnier, Soëli ; Blein, Tifanie ; Kergaravat, Camille ; Alcantara, Marion ; Villarese, Patrick ; Berthaud, Romain ; Dehoux, Laurène ; Albinni, Souha ; Karkeni, Esma ; Lagresle-Peyrou, Chantal ; Cavazzana, Marina ; Salomon, Rémi ; André, Isabelle ; Toubert, Antoine ; Asnafi, Vahid ; Picard, Capucine ; Blanche, Stéphane ; Macintyre, Elizabeth ; Boyer, Olivia ; Six, Emmanuelle ; Zuber, Julien ; Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité) ; Hôpital Necker - Enfants Malades AP-HP ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP) ; Institut de Recherche Saint-Louis - Hématologie Immunologie Oncologie (Département de recherche de l’UFR de médecine ; ex- Institut Universitaire Hématologie-IUH) (IRSL) ; Université Paris Cité (UPCité) ; Etablissement Français du Sang La Plaine Saint-Denis (EFS) ; Cytometrie et Biomarqueurs – Cytometry and Biomarkers (UTechS CB) ; Institut Pasteur Paris (IP)-Université Paris Cité (UPCité) ; This work was supported by funding from the Emmanuel Boussard and Day Solvay Foundations and the Agence Nationale de la Recherche (ANR-10-IAHU-01 “Investissements d’Avenir” program ; ANR-20-CE18-0004). We are grateful to Milena Hasan (Institut Pasteur) for critical advice on cytokine analysis. ; ANR-20-CE18-0004,DAISY,Thérapie Cellulaire Régulatrice Spécifique du Donneur par ingénierie génétique(2020) |
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| Zeitschrift: | ISSN: 0085-2538, 2023 |
| Veröffentlichung: | HAL CCSD ; Nature Publishing Group, 2023 |
| Medientyp: | academicJournal |
| DOI: | 10.1016/j.kint.2022.08.024 |
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