Is on-demand HIV pre-exposure prophylaxis a suitable tool for men who have sex with men who practice chemsex ? Results from a substudy of the ANRS-IPERGAY trial
In: ISSN: 1525-4135, 2018
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Zugriff:
International audience ; Background: Chemsex-the use of psychoactive substances during sexual encounters-among men who have sex with men is a growing concern. On-demand HIV pre-exposure prophylaxis (PrEP) may be a suitable tool to prevent HIV transmission among "chemsexers." We used the open-label extension study of the ANRS-IPERGAY trial to describe chemsexers and their PrEP use. Methods: Among the 361 men who have sex with men enrolled in ANRS-IPERGAY's open-label extension study, we selected the 331 with available data on drug use. A 2-monthly web questionnaire on sociobehavioral data was used to compare sexual behaviors between questionnaires where chemsex was reported and those where it was not. Using a generalized estimating equation logistic regression, we studied whether practicing chemsex was associated with correct PrEP use. Results: Among the 331 participants, 30% reported chemsex practice at least once during follow-up and were considered chemsexers. Chemsex was reported in 16% of all questionnaires. Chemsexers were not significantly different from nonchemsexers regarding sociodemographic characteristics, although they reported greater use of anxiolytics and more sensation-seeking. Reporting chemsex was associated with more high-risk sexual practices and a higher perception of risk. After adjustment for other potential correlates, chemsex remained associated with correct PrEP use [odds ratio (95% confidence interval) = 2.24 (1.37 to 3.66)]. Conclusions: Our findings show that chemsexers were more likely to report high-risk sexual practices but also had a higher perception of risk. They were also more likely to use PrEP correctly when practicing chemsex. Consequently, PrEP may be a suitable tool to reduce HIV-risk transmission among chemsexers.
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Is on-demand HIV pre-exposure prophylaxis a suitable tool for men who have sex with men who practice chemsex ? Results from a substudy of the ANRS-IPERGAY trial
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Autor/in / Beteiligte Person: | Roux, Perrine ; Fressard, Lisa ; Suzan-Monti, Marie ; Chas, Julie ; Sagaon-Teyssier, Luis ; Capitant, Catherine ; Meyer, Laurence ; Tremblay, Cécile ; Rojas-Castro, Daniela ; Pialoux, Gilles ; Molina, Jean-Michel ; Spire, Bruno ; Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD) ; Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM) ; Observatoire régional de la santé Provence-Alpes-Côte d'Azur Marseille (ORS PACA) ; CHU Tenon AP-HP ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU) ; Institut de Recherche pour le Développement (IRD) ; Essais Thérapeutiques et Maladies Infectieuses ; Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM) ; Essais Therapeutiques et Infection Par Le Vih ; Université de Montréal (UdeM) ; Groupe de Recherche en Psychologie Sociale (GRePS) ; Université Lumière - Lyon 2 (UL2) ; AIDES Pantin (Siège national) ; Institut Universitaire d'Hématologie (IUH) ; Université Paris Diderot - Paris 7 (UPD7) ; ANRS ; Canadian HIV Trials Network ; Fonds de Dotation Pierre Bergé pour la Prévention ; Gilead Sciences donated the TDF-FTC and placebo used in the study, and partly funded for the pharmacokinetics analysis. ; Bill and Melinda Gates Foundation |
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Zeitschrift: | ISSN: 1525-4135, 2018 |
Veröffentlichung: | HAL CCSD ; Lippincott, Williams & Wilkins, 2018 |
Medientyp: | academicJournal |
DOI: | 10.1097/QAI.0000000000001781 |
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