Search for copy number variants in chromosomes 15q11-q13 and 22q11.2 in obsessive compulsive disorder.
In: ISSN: 1471-2350 ; BMC Medical Genetics ; https://inserm.hal.science/inserm-00520828 ; BMC Medical Genetics, 2010, 11, pp.100. ⟨10.1186/1471-2350-11-100⟩, 2010
Online
academicJournal
Zugriff:
International audience ; BACKGROUND: Obsessive-compulsive disorder (OCD) is a clinically and etiologically heterogeneous syndrome. The high frequency of obsessive-compulsive symptoms reported in subjects with the 22q11.2 deletion syndrome (DiGeorge/velocardiofacial syndrome) or Prader-Willi syndrome (15q11-13 deletion of the paternally derived chromosome), suggests that gene dosage effects in these chromosomal regions could increase risk for OCD. Therefore, the aim of this study was to search for microrearrangements in these two regions in OCD patients. METHODS: We screened the 15q11-13 and 22q11.2 chromosomal regions for genomic imbalances in 236 patients with OCD using multiplex ligation-dependent probe amplification (MLPA). RESULTS: No deletions or duplications involving 15q11-13 or 22q11.2 were identified in our patients. CONCLUSIONS: Our results suggest that deletions/duplications of chromosomes 15q11-13 and 22q11.2 are rare in OCD. Despite the negative findings in these two regions, the search for copy number variants in OCD using genome-wide array-based methods is a highly promising approach to identify genes of etiologic importance in the development of OCD.
| Titel: |
Search for copy number variants in chromosomes 15q11-q13 and 22q11.2 in obsessive compulsive disorder.
|
|---|---|
| Autor/in / Beteiligte Person: | Delorme, Richard ; Moreno-De-Luca, Daniel ; Gennetier, Aurélie ; Maier, Wolfgang ; Chaste, Pauline ; Mössner, Rainald ; Grabe, Hans Jörgen ; Ruhrmann, Stephan ; Falkai, Peter ; Mouren, Marie-Christine ; Leboyer, Marion ; Wagner, Michael ; Betancur, Catalina ; Service de psychopathologie de l'enfant et de l'adolescent ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré-Université Paris Diderot - Paris 7 (UPD7) ; Institut Mondor de Recherche Biomédicale (IMRB) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12) ; Physiopathologie des Maladies du Système Nerveux Central ; Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) ; Department of Psychiatry and Psychotherapy ; Rheinische Friedrich-Wilhelms-Universität Bonn ; Universität Greifswald - University of Greifswald ; University of Cologne ; Georg-August-University = Georg-August-Universität Göttingen ; Institut Universitaire d'Hématologie (IUH) ; Université Paris Diderot - Paris 7 (UPD7) ; This research was supported by INSERM, Fondation de France, FondaMental Foundation, and the German Research Foundation (DFG). |
| Link: | |
| Zeitschrift: | ISSN: 1471-2350 ; BMC Medical Genetics ; https://inserm.hal.science/inserm-00520828 ; BMC Medical Genetics, 2010, 11, pp.100. ⟨10.1186/1471-2350-11-100⟩, 2010 |
| Veröffentlichung: | HAL CCSD ; BioMed Central, 2010 |
| Medientyp: | academicJournal |
| DOI: | 10.1186/1471-2350-11-100 |
| Schlagwort: |
|
| Sonstiges: |
|