Certain leukocyte IgG receptors affect immunity to Streptococcus pneumoniae.
In: Biotech Week, 2003-08-06, S. 499-500
serialPeriodical
Zugriff:
According to a study from the Netherlands and Iceland, members of the leukocyte immunoglobulin (Ig) G receptor (Fc-gamma-R) family play a key role in antibody-mediated phagocytosis and can either enhance antigen presentation or down-modulate immune responses. Researchers studied immune responses to a pneumococcal conjugate (pneumococcal polysaccharide serotype 1 [PPS1]-tetanus toxoid) and antibody-mediated protection in mice deficient for individual Fc-gamma-Rs and complement receptor 3 (CR3). FcR gamma chain-deficient (FcR gamma chain-/-) mice, which lack expression of both Fc-gamma-RI and III, had significantly lower anti-PPS1 IgG2b and IgG3 responses than did wild-type mice, whereas Fc-gamma-RII-deficient (Fc-gamma-RII-/-) mice had significantly higher IgG2a and IgG3 titers. These data indicate that activatory leukocyte Fcgamma-R, but not Fc-gamma-RII (a murine homologue of human Fc-gamma-RIIb), contributes to IgG-mediated protection against pneumococcal disease.
Titel: |
Certain leukocyte IgG receptors affect immunity to Streptococcus pneumoniae.
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Zeitschrift: | Biotech Week, 2003-08-06, S. 499-500 |
Veröffentlichung: | 2003 |
Medientyp: | serialPeriodical |
ISSN: | 1535-2757 (print) |
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