New Bioinformatics Data Have Been Reported by Researchers at University of Delhi (DU) [Therapeutic potential of polyphenols against aging- induced idiopathic pulmonary fibrosis (IPF) via Bioinformatics analysis].

Researchers at the University of Delhi have conducted a study on the therapeutic potential of polyphenols in treating idiopathic pulmonary fibrosis (IPF) in the elderly population. The study focused on the activation of the Aryl hydrocarbon receptor (AhR) and its role in inhibiting the Akt/mTORC1 pathway, which is known to drive IPF. Through molecular docking and ADMET analysis, the researchers identified baicalin and luteolin as the most promising polyphenols for suppressing mTORC1 and inducing autophagy, potentially mitigating IPF in aging individuals. This research suggests that flavonoid formulations targeting AhR activation could be considered as a therapeutic approach for IPF during biological aging. [Extracted from the article]

Copyright of Respiratory Therapeutics Week is the property of NewsRx and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)