Effects of taurine on resting-state fMRI activity in spontaneously hypertensive rats.
In: PLoS ONE, Jg. 12 (2017-07-10), Heft 7, S. 1-15
academicJournal
Zugriff:
Attention deficit hyperactivity disorder (ADHD) is a global behavior illness among children and adults. To investigate the effects of taurine on resting-state fMRI activity in ADHD, a spontaneously hypertensive rat (SHR) animal model was adopted. Significantly decreased serum C-reactive protein (CRP) was detected in rats of Wistar Kyoto (WKY) high-taurine group and significantly decreased interleukin (IL)-1β and CRP were detected in rats of SHR low-taurine and high-taurine groups. Moreover, significantly higher horizontal locomotion was detected in rats of WKY low-taurine and SHR low-taurine groups than in those of controls. In contrast, significantly lower horizontal locomotion was detected in rats of the SHR high-taurine group than in those of the SHR control group. Additionally, significantly lower functional connectivity (FC) and mean amplitude of low-frequency fluctuation (mALFF) in the bilateral hippocampus in rats of WKY high-taurine and SHR high-taurine groups was detected. Notably, the mALFF in rats of the SHR low-taurine and high-taurine groups was significantly lower than in those of the SHR control group. These findings suggest that the administration of a high-dose taurine probably improves hyperactive behavior in SHR rats by ameliorating the inflammatory cytokines and modulating brain functional signals in SHR rats. [ABSTRACT FROM AUTHOR]
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Titel: |
Effects of taurine on resting-state fMRI activity in spontaneously hypertensive rats.
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Autor/in / Beteiligte Person: | Chen, Vincent Chin-Hung ; Hsu, Tsai-Ching ; Chen, Li-Jeng ; Chou, Hong-Chun ; Weng, Jun-Cheng ; Tzang, Bor-Show |
Zeitschrift: | PLoS ONE, Jg. 12 (2017-07-10), Heft 7, S. 1-15 |
Veröffentlichung: | 2017 |
Medientyp: | academicJournal |
ISSN: | 1932-6203 (print) |
DOI: | 10.1371/journal.pone.0181122 |
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