Differential expression of glycine receptor subunits in the retina of the rat: a study using immunohistochemistry and in situ hybridization.
In: Visual neuroscience, Jg. 11 (1994-07-01), Heft 4, S. 721-9
academicJournal
Zugriff:
Immunohistochemistry and in situ hybridization were used to study the distribution of glycine receptor (GlyR) subunits and the GlyR-associated protein gephyrin in the rat retina. Monoclonal antibodies against the alpha and beta subunits of the GlyR and gephyrin showed a strong punctate labeling pattern in the inner plexiform layer. Glycine receptor mRNAs were found in the inner nuclear layer and the ganglion cell layer. The alpha 1 subunit mRNA is predominantly present in the outer half of the INL and on some but not all ganglion cells. GlyR alpha 2 subunit mRNA is predominantly present in the inner half of the INL and on nearly all cells in the ganglion cell layer. GlyR alpha 3-, GlyR beta-, and gephyrin-mRNAs are present in the entire INL and in cells in the ganglion cell layer. The differential expression of glycine receptor subunits indicates a functional diversity of glycine receptors in the retina.
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Differential expression of glycine receptor subunits in the retina of the rat: a study using immunohistochemistry and in situ hybridization.
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Autor/in / Beteiligte Person: | Greferath, U ; Brandstätter, JH ; Wässle, H ; Kirsch, J ; Kuhse, J ; Grünert, U |
Zeitschrift: | Visual neuroscience, Jg. 11 (1994-07-01), Heft 4, S. 721-9 |
Veröffentlichung: | Cambridge, England : Cambridge University Press ; <i>Original Publication</i>: New York, NY, USA : Cambridge University Press, c1988-, 1994 |
Medientyp: | academicJournal |
ISSN: | 0952-5238 (print) |
DOI: | 10.1017/s0952523800003023 |
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