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Associations of Intrapancreatic Fat Deposition With Incident Diseases of the Exocrine and Endocrine Pancreas: A UK Biobank Prospective Cohort Study.

Dong, X ; Zhu, Q ; et al.
In: The American journal of gastroenterology, Jg. 119 (2024-06-01), Heft 6, S. 1158-1166
academicJournal

Titel:
Associations of Intrapancreatic Fat Deposition With Incident Diseases of the Exocrine and Endocrine Pancreas: A UK Biobank Prospective Cohort Study.
Autor/in / Beteiligte Person: Dong, X ; Zhu, Q ; Yuan, C ; Wang, Y ; Ma, X ; Shi, X ; Chen, W ; Dong, Z ; Chen, L ; Shen, Q ; Xu, H ; Ding, Y ; Gong, W ; Xiao, W ; Wang, S ; Li, W ; Lu, G
Zeitschrift: The American journal of gastroenterology, Jg. 119 (2024-06-01), Heft 6, S. 1158-1166
Veröffentlichung: <2019-> : [Philadelphia, PA] : Wolters Kluwer Health ; <i>Original Publication</i>: New York, Elsevier Science, -2003., 2024
Medientyp: academicJournal
ISSN: 1572-0241 (electronic)
DOI: 10.14309/ajg.0000000000002792
Schlagwort:
  • Humans
  • Female
  • Male
  • Middle Aged
  • Prospective Studies
  • United Kingdom epidemiology
  • Aged
  • Adult
  • Magnetic Resonance Imaging
  • Pancreatitis epidemiology
  • Risk Factors
  • Biological Specimen Banks
  • Incidence
  • Pancreatic Neoplasms epidemiology
  • Pancreatic Neoplasms pathology
  • Intra-Abdominal Fat diagnostic imaging
  • Prevalence
  • Diabetes Mellitus epidemiology
  • Pancreas, Exocrine metabolism
  • Proportional Hazards Models
  • Pancreas diagnostic imaging
  • Pancreas pathology
  • Pancreas metabolism
  • UK Biobank
  • Pancreatic Diseases epidemiology
  • Pancreatic Diseases metabolism
  • Pancreatic Diseases diagnostic imaging
Sonstiges:
  • Nachgewiesen in: MEDLINE
  • Sprachen: English
  • Publication Type: Journal Article
  • Language: English
  • [Am J Gastroenterol] 2024 Jun 01; Vol. 119 (6), pp. 1158-1166. <i>Date of Electronic Publication: </i>2024 Apr 08.
  • MeSH Terms: Pancreatic Diseases* / epidemiology ; Pancreatic Diseases* / metabolism ; Pancreatic Diseases* / diagnostic imaging ; Humans ; Female ; Male ; Middle Aged ; Prospective Studies ; United Kingdom / epidemiology ; Aged ; Adult ; Magnetic Resonance Imaging ; Pancreatitis / epidemiology ; Risk Factors ; Biological Specimen Banks ; Incidence ; Pancreatic Neoplasms / epidemiology ; Pancreatic Neoplasms / pathology ; Intra-Abdominal Fat / diagnostic imaging ; Prevalence ; Diabetes Mellitus / epidemiology ; Pancreas, Exocrine / metabolism ; Proportional Hazards Models ; Pancreas / diagnostic imaging ; Pancreas / pathology ; Pancreas / metabolism ; UK Biobank
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Fatty pancreas is independently associated with subsequent diabetes mellitus development: A 10-year prospective cohort study. Clin Gastroenterol Hepatol 2022;20(9):2014–22.e4. ; Ko J, Skudder-Hill L, Priya S, et al. Associations between intra-pancreatic fat deposition, pancreas size, and pancreatic enzymes in health and after an attack of acute pancreatitis. Obes Facts 2022;15(1):70–82. ; Kromrey ML, Friedrich N, Hoffmann RT, et al. Pancreatic steatosis is associated with impaired exocrine pancreatic function. Invest Radiol 2019;54(7):403–8. ; Kuhn JP, Hernando D, Munoz del Rio A, et al. Effect of multipeak spectral modeling of fat for liver iron and fat quantification: Correlation of biopsy with MR imaging results. Radiology 2012;265(1):133–42. ; Collins R. What makes UK Biobank special? Lancet 2012;379(9822):1173–4. ; Kart T, Fischer M, Kustner T, et al. 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Eur J Gastroenterol Hepatol 2019;31(8):973–8. ; Rebours V, Gaujoux S, d'Assignies G, et al. Obesity and fatty pancreatic infiltration are risk factors for pancreatic precancerous lesions (PanIN). Clin Cancer Res 2015;21(15):3522–8. ; Ko J, Stuart CE, Modesto AE, et al. Chronic pancreatitis is characterized by elevated circulating periostin levels related to intra-pancreatic fat deposition. J Clin Med Res 2020;12(9):568–78. ; Heiskanen MA, Motiani KK, Mari A, et al. Exercise training decreases pancreatic fat content and improves beta cell function regardless of baseline glucose tolerance: A randomised controlled trial. Diabetologia 2018;61(8):1817–28. ; Skudder-Hill L, Sequeira IR, Cho J, et al. Fat distribution within the pancreas according to diabetes status and insulin traits. Diabetes 2022;71(6):1182–92.
  • Grant Information: 82200680 National Natural Science Foundation of China; 82200720 National Natural Science Foundation of China; 82200721 National Natural Science Foundation of China; 82070996 National Natural Science Foundation of China; 82241043 National Natural Science Foundation of China; 82173616 National Natural Science Foundation of China; YZ2021147 Natural ScienCultivation Foundation of Yangzhou Municipal Key Laboratoryce Foundation of Yangzhou Municipality; ZD2022011 The Medical research Project of Jiangsu Provincial Health Commission; YZ2022080 Yangzhou key research and development plan; SZS2023001 Suzhou Innovation Platform Construction Projects- Municipal Key Laboratory Construction
  • Entry Date(s): Date Created: 20240408 Date Completed: 20240604 Latest Revision: 20240620
  • Update Code: 20240620
  • PubMed Central ID: PMC11142652

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