Einzeltreffer — DigiBib

Delivering cargo to the central nervous system (CNS) remains a pharmacological challenge. For infectious diseases such as HIV, the CNS acts as a latent reservoir that is inadequately managed by systemic antiretrovirals (ARTs). ARTs thus cannot eradicate HIV, and given CNS infection, patients experience neurological deficits collectively referred to as "neuroHIV". Herein, the development of bioinspired ionic liquid-coated nanoparticles (IL-NPs) for in situ hitchhiking on red blood cells (RBCs) is reported, which enables 48% brain delivery of intracarotid arterial- infused cargo. Moreover, IL choline trans-2-hexenoate (CA2HA 1:2) demonstrates preferential accumulation in parenchymal microglia over endothelial cells post-delivery. This study further demonstrates successful loading of abacavir (ABC), an ART that is challenging to encapsulate, into IL-NPs, and verifies retention of antiviral efficacy in vitro. IL-NPs are not cytotoxic to primary human peripheral blood mononuclear cells (PBMCs) and the CA2HA 1:2 coating itself confers notable anti-viremic capacity. In addition, in vitro cell culture assays show markedly increased uptake of IL-NPs into neural cells compared to bare PLGA nanoparticles. This work debuts bioinspired ionic liquids as promising nanoparticle coatings to assist CNS biodistribution and has the potential to revolutionize the delivery of cargos (i.e., drugs, viral vectors) through compartmental barriers such as the blood-brain-barrier (BBB).

Titel:	Ionic Liquid Coating-Driven Nanoparticle Delivery to the Brain: Applications for NeuroHIV.
Autor/in / Beteiligte Person:	Hamadani, CM ; Mahdi, F ; Merrell, A ; Flanders, J ; Cao, R ; Vashisth, P ; Dasanayake, GS ; Darlington, DS ; Singh, G ; Pride, MC ; Monroe, WG ; Taylor, GR ; Hunter, AN ; Roman, G ; Paris, JJ ; Tanner, EEL
Zeitschrift:	Advanced science (Weinheim, Baden-Wurttemberg, Germany), Jg. 11 (2024-06-01), Heft 23, S. e2305484
Veröffentlichung:	Weinheim : WILEY-VCH, [2014]-, 2024
Medientyp:	academicJournal
ISSN:	2198-3844 (electronic)
DOI:	10.1002/advs.202305484
Schlagwort:	Animals Humans Rats Drug Delivery Systems methods Blood-Brain Barrier metabolism Blood-Brain Barrier drug effects Mice Male Nanoparticles chemistry Nanoparticles administration & dosage Brain metabolism Brain drug effects Ionic Liquids chemistry HIV Infections drug therapy
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Adv Sci (Weinh)] 2024 Jun; Vol. 11 (23), pp. e2305484. <i>Date of Electronic Publication: </i>2024 Apr 04. MeSH Terms: Nanoparticles* / chemistry ; Nanoparticles* / administration & dosage ; Brain* / metabolism ; Brain* / drug effects ; Ionic Liquids* / chemistry ; HIV Infections* / drug therapy ; Animals ; Humans ; Rats ; Drug Delivery Systems / methods ; Blood-Brain Barrier / metabolism ; Blood-Brain Barrier / drug effects ; Mice ; Male Comments: Update of: Res Sq. 2023 Feb 14:rs.3.rs-2574352. doi: 10.21203/rs.3.rs-2574352/v1. (PMID: 36824802) References: J Neuroimmune Pharmacol. 2019 Mar;14(1):110-119. (PMID: 30194646) ; Sci Adv. 2019 Nov 13;5(11):eaax9250. (PMID: 31763454) ; ACS Nano. 2013 Dec 23;7(12):11129-37. (PMID: 24182189) ; Nat Commun. 2019 Jul 2;10(1):2753. (PMID: 31266936) ; Phys Chem Chem Phys. 2012 Aug 7;14(29):10119-21. (PMID: 22735595) ; Pharmaceutics. 2020 May 09;12(5):. (PMID: 32397513) ; Adv Sci (Weinh). 2021 Sep;8(17):e2004819. (PMID: 34245140) ; J Control Release. 2020 Nov 10;327:26-34. (PMID: 32735879) ; Nature. 2001 Apr 19;410(6831):980-7. (PMID: 11309628) ; Front Microbiol. 2017 Aug 24;8:1608. (PMID: 28883814) ; Mol Cancer Ther. 2014 Dec;13(12):2805-16. (PMID: 25281618) ; Clin Microbiol Rev. 2004 Oct;17(4):942-64, table of contents. (PMID: 15489356) ; Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13193-7. (PMID: 9371822) ; Curr HIV/AIDS Rep. 2015 Jun;12(2):299-303. (PMID: 25869939) ; Nat Protoc. 2023 Aug;18(8):2509-2557. (PMID: 37468651) ; Annu Rev Neurosci. 2002;25:537-62. (PMID: 12052920) ; Chem Rev. 2020 Jul 8;120(13):5798-5877. (PMID: 32292036) ; Front Cell Infect Microbiol. 2019 Mar 22;9:69. (PMID: 30968001) ; Proc Natl Acad Sci U S A. 2019 Dec 10;116(50):25042-25047. (PMID: 31767747) ; Curr Opin HIV AIDS. 2016 Jul;11(4):417-23. (PMID: 27078619) ; J Neurosci Res. 2003 Jul 15;73(2):141-55. (PMID: 12836157) ; Trends Neurosci. 2020 Sep;43(9):695-708. (PMID: 32682564) ; Nat Commun. 2018 Jul 11;9(1):2684. (PMID: 29992966) ; Curr Protoc Immunol. 2014 Feb 04;104:14.35.1-14.35.15. (PMID: 24510618) ; Neurosci Lett. 2019 Nov 1;712:134475. (PMID: 31491466) ; Nanoscale. 2022 Apr 21;14(16):6021-6036. (PMID: 35362493) ; J Neurovirol. 2015 Jun;21(3):227-34. (PMID: 25366659) ; Int J Pharm. 2009 Jan 5;365(1-2):180-9. (PMID: 18790029) ; Mol Pharm. 2021 Aug 2;18(8):3108-3115. (PMID: 34250805) ; Biochem J. 1996 Dec 15;320 ( Pt 3):817-24. (PMID: 9003367) ; Sci Transl Med. 2020 May 13;12(543):. (PMID: 32404504) ; J Neuroimmune Pharmacol. 2021 Mar;16(1):74-89. (PMID: 31209776) ; RSC Adv. 2022 Jan 28;12(6):3687-3695. (PMID: 35425367) ; PLoS Comput Biol. 2019 Aug 30;15(8):e1007231. (PMID: 31469820) ; J Neurochem. 2021 Jul;158(2):429-443. (PMID: 33655498) ; Sci Adv. 2020 Nov 25;6(48):. (PMID: 33239302) ; Am J Physiol Cell Physiol. 2000 May;278(5):C921-30. (PMID: 10794666) ; Blood. 2008 Dec 1;112(12):4729-38. (PMID: 18796630) ; Nat Commun. 2022 Jan 10;13(1):121. (PMID: 35013215) ; Cell Host Microbe. 2019 Sep 11;26(3):347-358.e7. (PMID: 31471273) ; AIMS Neurosci. 2020 Apr 20;7(2):94-106. (PMID: 32607414) ; Retrovirology. 2021 Dec 18;18(1):39. (PMID: 34922576) ; Chembiochem. 2020 Jan 15;21(1-2):45-52. (PMID: 31553512) ; Adv Sci (Weinh). 2024 Jun;11(23):e2305484. (PMID: 38572510) ; Front Cell Infect Microbiol. 2019 Oct 24;9:362. (PMID: 31709195) ; Retrovirology. 2017 Oct 16;14(1):47. (PMID: 29037245) ; AAPS J. 2020 Jun 11;22(4):84. (PMID: 32529599) ; EMBO J. 2019 Sep 2;38(17):e101997. (PMID: 31373067) ; J Control Release. 2018 Sep 28;286:137-144. (PMID: 30026081) ; PLoS Pathog. 2020 Jun 11;16(6):e1008381. (PMID: 32525948) ; Anat Embryol (Berl). 1985;171(2):129-38. (PMID: 3985362) Grant Information: 1726880 National Science Foundation; Pharmaceutical Research and Manufacturers of America Foundation (PhRMA); P30GM122733 United States NH NIH HHS; P30 GM122733 United States GM NIGMS NIH HHS; 2236629 National Science Foundation; R21 GM103460 United States GM NIGMS NIH HHS; R01DA056875 United States NH NIH HHS; G0315202198510166 Sigma Xi Grants in Aid of Research; P20GM103460 United States NH NIH HHS; University of Mississippi iDRUM Initiative; R01 DA056875 United States DA NIDA NIH HHS; College of Liberal Arts at the University of Mississippi Contributed Indexing: Keywords: brain delivery; cellular hitchhiking; ionic liquids; nanoparticles; red blood cells Substance Nomenclature: 0 (Ionic Liquids) Entry Date(s): Date Created: 20240404 Date Completed: 20240619 Latest Revision: 20240621 Update Code: 20240621 PubMed Central ID: PMC11186118

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.

Ionic Liquid Coating-Driven Nanoparticle Delivery to the Brain: Applications for NeuroHIV.