The antibacterial and hemostatic curdlan hydrogel-loading epigallocatechin gallate for facilitating the infected wound healing.

Ding, Q ; Mo, Z ; et al.

In: International journal of biological macromolecules, Jg. 266 (2024-05-01), Heft Pt 1, S. 131257

academicJournal

The infected wounds pose one of the major threats to human health today. To address this issue, it is necessary to develop innovative wound dressings with superior antibacterial activity and other properties. Due to its potent antibacterial, antioxidant, and immune-boosting properties, epigallocatechin gallate (EGCG) has been widely utilized. In this study, a multifunctional curdlan hydrogel loading EGCG (Cur-EGCGH3) was designed. Cur-EGCGH3 exhibited excellent physicochemical properties, good biocompatibility, hemostatic, antibacterial, and antioxidant activities. Also, ELISA data showed that Cur-EGCGH3 stimulated macrophages to secrete pro-inflammatory and pro-regenerative cytokines. Cell scratch results indicated that Cur-EGCGH3 promoted the migration of NIH3T3 and HUVECs. In vivo experiments confirmed that Cur-EGCGH3 could inhibit bacterial infection of the infected wounds, accelerate hemostasis, and promote epithelial regeneration and collagen deposition. These results demonstrated that Cur-EGCGH3 holds promise for promoting healing of the infected wounds.

Competing Interests: Declaration of competing interest All authors declare that there are no potential conflicts of interest. All authors have reviewed and approved the manuscript and are willing to attest to their qualifications as authors, disclose potential conflicts of interest, and release copyright should the manuscript be accepted for publication.

Titel:	The antibacterial and hemostatic curdlan hydrogel-loading epigallocatechin gallate for facilitating the infected wound healing.
Autor/in / Beteiligte Person:	Ding, Q ; Mo, Z ; Wang, X ; Chen, M ; Zhou, F ; Liu, Z ; Long, Y ; Xia, X ; Zhao, P
Zeitschrift:	International journal of biological macromolecules, Jg. 266 (2024-05-01), Heft Pt 1, S. 131257
Veröffentlichung:	Amsterdam : Elsevier ; <i>Original Publication</i>: Guildford, Eng., IPC Science and Technology Press., 2024
Medientyp:	academicJournal
ISSN:	1879-0003 (electronic)
DOI:	10.1016/j.ijbiomac.2024.131257
Schlagwort:	Animals Mice Humans NIH 3T3 Cells Wound Infection drug therapy Wound Infection microbiology Antioxidants pharmacology Antioxidants chemistry Human Umbilical Vein Endothelial Cells drug effects Catechin analogs & derivatives Catechin pharmacology Catechin chemistry Wound Healing drug effects beta-Glucans chemistry beta-Glucans pharmacology Hydrogels chemistry Hydrogels pharmacology Anti-Bacterial Agents pharmacology Anti-Bacterial Agents chemistry Hemostatics pharmacology Hemostatics chemistry
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Int J Biol Macromol] 2024 May; Vol. 266 (Pt 1), pp. 131257. <i>Date of Electronic Publication: </i>2024 Mar 29. MeSH Terms: Catechin* / analogs & derivatives ; Catechin / pharmacology ; Catechin* / chemistry ; Wound Healing* / drug effects ; beta-Glucans* / chemistry ; beta-Glucans* / pharmacology ; Hydrogels* / chemistry ; Hydrogels* / pharmacology ; Anti-Bacterial Agents* / pharmacology ; Anti-Bacterial Agents* / chemistry ; Hemostatics* / pharmacology ; Hemostatics* / chemistry ; Animals ; Mice ; Humans ; NIH 3T3 Cells ; Wound Infection / drug therapy ; Wound Infection / microbiology ; Antioxidants / pharmacology ; Antioxidants / chemistry ; Human Umbilical Vein Endothelial Cells / drug effects Contributed Indexing: Keywords: Antibacterial; Curdlan; Epigallocatechin gallate; Infected wound healing Substance Nomenclature: 8R1V1STN48 (Catechin) ; BQM438CTEL (epigallocatechin gallate) ; 0 (beta-Glucans) ; 0 (Hydrogels) ; 0 (Anti-Bacterial Agents) ; 0 (Hemostatics) ; 6930DL209R (curdlan) ; 0 (Antioxidants) Entry Date(s): Date Created: 20240330 Date Completed: 20240430 Latest Revision: 20240430 Update Code: 20240430

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.