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Background: Although endoscopic mastectomy has been associated with good tolerance and enhanced patient satisfaction, limitations such as the implant or flap size for reconstruction with small incisions remain unresolved. Fat grafting (FG) can expand tissue volume with pinhole skin incisions. Herein, we evaluated the safety and efficacy of endoscopic mastectomy followed by immediate FG.

Methods: Patients who underwent endoscopic mastectomy with immediate FG reconstruction from 2015 to 2021 were retrospectively evaluated to establish surgical outcomes and prognosis.

Results: Twenty-three patients with clinical stage 0 or I breast cancer underwent unilateral endoscopic mastectomy with immediate FG. The median age was 45 years (41-55), and the median body mass index was 19.3 kg/m 2 (15.8-26.6). Endoscopically performed procedures included skin-sparing mastectomies in 18 patients (78%) and nipple-sparing mastectomies in five patients (22%). The median procedure duration was 295 min (242-346). The median specimen weight was 133 g (71-334), and the median grafted fat volume was 200 mL (136-320). No patient required reoperation or additional procedures for complications. One patient experienced recurrence at a median follow-up of 56.1 months and underwent resection; the patient was alive without recurrence 54 months post-resection.

Conclusion: To the best of our knowledge, this is the first report of endoscopic mastectomy with immediate FG for reconstruction. When compared with other immediate autologous reconstructions, our strategy could minimize the skin incision and procedure duration, as well as limit complications. Further prospective investigations are needed to evaluate oncological safety, surgical outcomes, and patient satisfaction.

Titel:	Endoscopic mastectomy followed by immediate breast reconstruction with fat grafting for breast cancer.
Autor/in / Beteiligte Person:	Narui, K ; Satake, T ; Ishikawa, T ; Muto, M ; Tsunoda, Y ; Yamada, A ; Kawashima, K ; Uenaka, N ; Fujiwara, Y ; Oshi, M ; Adachi, S ; Suzuki, C ; Wada, T ; Yamamoto, S ; Tanabe, M ; Maegawa, J ; Endo, I
Zeitschrift:	Breast cancer (Tokyo, Japan), Jg. 31 (2024-05-01), Heft 3, S. 476-484
Veröffentlichung:	Tokyo : Maruzen Co.,, 2024
Medientyp:	academicJournal
ISSN:	1880-4233 (electronic)
DOI:	10.1007/s12282-024-01561-x
Schlagwort:	Humans Female Middle Aged Adult Retrospective Studies Adipose Tissue transplantation Treatment Outcome Patient Satisfaction Follow-Up Studies Mammaplasty methods Endoscopy methods Breast Neoplasms surgery Breast Neoplasms pathology Mastectomy methods Mastectomy adverse effects
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Breast Cancer] 2024 May; Vol. 31 (3), pp. 476-484. <i>Date of Electronic Publication: </i>2024 Mar 21. MeSH Terms: Mammaplasty* / methods ; Endoscopy* / methods ; Breast Neoplasms* / surgery ; Breast Neoplasms* / pathology ; Mastectomy* / methods ; Mastectomy* / adverse effects ; Humans ; Female ; Middle Aged ; Adult ; Retrospective Studies ; Adipose Tissue / transplantation ; Treatment Outcome ; Patient Satisfaction ; Follow-Up Studies References: Soybir G, Fukuma E. Endoscopy assisted oncoplastic breast surgery (EAOBS). J Breast Health. 2015;11:52–8. (PMID: 10.5152/tjbh.2015.2520283316925351487) ; Mok CW, Lai HW. Endoscopic-assisted surgery in the management of breast cancer: 20 years review of trend, techniques and outcomes. Breast. 2019;46:144–56. (PMID: 10.1016/j.breast.2019.05.01331176887) ; Nakajima H, Fujiwara I, Mizuta N, Sakaguchi K, Hachimine Y. 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Endoscopic mastectomy followed by immediate breast reconstruction with fat grafting for breast cancer.