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Metaplastic carcinoma of the breast (MpBC) is a very rare and aggressive type of breast cancer. Data focusing on MpBC are limited. The aim of this study was to describe the clinicopathological features of MpBC and evaluate the prognosis of patients with MpBC. Eligible articles about MpBC were identified by searching CASES SERIES gov and the MEDLINE bibliographic database for the period of 1 January 2010 to 1 June 2021 with the keywords metaplastic breast cancer, mammary gland cancer, neoplasm, tumor, and metaplastic carcinoma. In this study, we also report 46 cases of MpBC stemming from our hospital. Survival rates, clinical behavior, and pathological characteristics were analyzed. Data from 205 patients were included for analysis. The mean age at diagnosis was 55 (14.7) years. The TNM stage at diagnosis was mostly stage II (58.5%) and most tumors were triple negative. The median overall survival was 66 (12-118) months, and the median disease-free survival was 56.8 (11-102) months. Multivariate Cox regression analysis revealed that surgical treatment was associated with decreased risk of death (hazard ratio 0.11, 95% confidence interval 0.02-0.54, p = 0.01) while advanced TNM stage was associated with increased risk of death (hazard ratio 1.5, 95% confidence interval 1.04-2.28, p = 0.03). Our results revealed that surgical treatment and TNM stage were the only independent risk factors related to patients' overall survival.

Titel:	Metaplastic Carcinoma of the Breast: Case Series of a Single Institute and Review of the Literature.
Autor/in / Beteiligte Person:	Papatheodoridi, A ; Papamattheou, E ; Marinopoulos, S ; Ntanasis-Stathopoulos, I ; Dimitrakakis, C ; Giannos, A ; Kaparelou, M ; Liontos, M ; Dimopoulos, MA ; Zagouri, F
Zeitschrift:	Medical sciences (Basel, Switzerland), Jg. 11 (2023-05-19), Heft 2
Veröffentlichung:	Basel, Switzerland : MDPI AG, [2013]-, 2023
Medientyp:	academicJournal
ISSN:	2076-3271 (electronic)
DOI:	10.3390/medsci11020035
Schlagwort:	Humans Middle Aged Female Breast pathology Prognosis Disease-Free Survival Carcinoma, Ductal, Breast pathology Carcinoma, Ductal, Breast therapy Breast Neoplasms
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Review Language: English [Med Sci (Basel)] 2023 May 19; Vol. 11 (2). <i>Date of Electronic Publication: </i>2023 May 19. MeSH Terms: Carcinoma, Ductal, Breast* / pathology ; Carcinoma, Ductal, Breast* / therapy ; Breast Neoplasms* ; Humans ; Middle Aged ; Female ; Breast / pathology ; Prognosis ; Disease-Free Survival References: Ger Med Sci. 2017 Dec 06;15:Doc17. (PMID: 29255401) ; Front Endocrinol (Lausanne). 2021 Apr 23;12:628939. (PMID: 33972826) ; Breast J. 2020 May;26(5):1031-1032. (PMID: 31793094) ; In Vivo. 2017 Jul-Aug;31(4):737-740. (PMID: 28652449) ; Breast Care (Basel). 2011;6(3):230-233. (PMID: 21779230) ; Am J Case Rep. 2018 Feb 23;19:203-206. (PMID: 29472521) ; Oncol Lett. 2013 Sep;6(3):728-732. (PMID: 24137400) ; Int J Clin Exp Pathol. 2014 Jul 15;7(8):5215-20. (PMID: 25197400) ; Breast Cancer Res Treat. 2010 Apr;120(3):627-37. 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(PMID: 24051928) Contributed Indexing: Keywords: breast cancer; metaplastic carcinoma; triple-negative breast cancer Entry Date(s): Date Created: 20230523 Date Completed: 20230524 Latest Revision: 20230525 Update Code: 20231215 PubMed Central ID: PMC10204473

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Metaplastic Carcinoma of the Breast: Case Series of a Single Institute and Review of the Literature.