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We studied the relationship between the level of cytokines in the lymph of the thoracic duct and the morphometric parameters of the mesenteric lymph nodes after surgical treatment of breast cancer, chemotherapy, and administration of fragmented (double-stranded, dsDNA) human DNA. In comparison with surgical treatment and with chemotherapy alone, administration of a human dsDNA has a stimulating effect on the T-cell link of the immune response. In the paracortical zone, the relationship between the chemokine MCP-1 and increased content of small lymphocytes in this zone was revealed. Interrelations of IL-2 cytokines with small lymphocytes and of IL-4 with medium lymphocytes were revealed in germinal centers. We also observed interrelations of IL-7 with small lymphocytes and IL-4 with macrophages in the medullary cords, chemokine MIP-1α with immature and mature plasma cells (the number of these cells is reduced), and of MCP-1 with immunoblasts (the number of which is also reduced) in the medullary sinuses.

Titel:	Correlation of Cytokine Content in the Lymph with the Morphological Parameters of the Mesenteric Lymph Nodes in Adjuvant Therapy of Experimental Breast Cancer with the Use of Fragmented Human DNA.
Autor/in / Beteiligte Person:	Kazakov, OV ; Poveshchenko, AF ; Kabakov, AV ; Konenkov, VI
Zeitschrift:	Bulletin of experimental biology and medicine, Jg. 174 (2022-11-01), Heft 1, S. 104-108
Veröffentlichung:	New York : Springer ; <i>Original Publication</i>: New York, Consultants Bureau., 2022
Medientyp:	academicJournal
ISSN:	1573-8221 (electronic)
DOI:	10.1007/s10517-022-05657-2
Schlagwort:	Female Chemokines metabolism Interleukin-4 metabolism Lymph metabolism Animals Rats Rats, Wistar T-Lymphocytes immunology Breast Neoplasms drug therapy Breast Neoplasms surgery Breast Neoplasms therapy Cytokines metabolism DNA administration & dosage Lymph Nodes metabolism Mammary Neoplasms, Animal drug therapy Mammary Neoplasms, Animal surgery Mammary Neoplasms, Animal therapy Adjuvants, Immunologic administration & dosage
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Bull Exp Biol Med] 2022 Nov; Vol. 174 (1), pp. 104-108. <i>Date of Electronic Publication: </i>2022 Nov 28. MeSH Terms: Breast Neoplasms* / drug therapy ; Breast Neoplasms* / surgery ; Breast Neoplasms* / therapy ; Cytokines* / metabolism ; DNA* / administration & dosage ; Lymph Nodes* / metabolism ; Mammary Neoplasms, Animal* / drug therapy ; Mammary Neoplasms, Animal* / surgery ; Mammary Neoplasms, Animal* / therapy ; Adjuvants, Immunologic* / administration & dosage ; Female ; Chemokines / metabolism ; Interleukin-4 / metabolism ; Lymph / metabolism ; Animals ; Rats ; Rats, Wistar ; T-Lymphocytes / immunology References: DeSantis CE, Ma J, Gaudet MM, Newman LA, Miller KD, Goding Sauer A, Jemal A, Siegel RL. Breast cancer statistics, 2019. CA Cancer J. Clin. 2019;69(6):438-451. doi: https://doi.org/10.3322/caac.215839 . 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Gos. Univer. Ser. Biol. Klin. Med. 2013;11(4):67-82. Russian. ; Kabakov AV, Lykov AP, Morozov DV, Kazakov OV, Poveshchenko AF, Raiter TV, Strunkin DN, Konenkov VI. Phenotypical characteristics of chemically induced mammary tumor. Bull. Exp. Biol. Med. 2017;163(4):490-492. doi: https://doi.org/10.1007/s10517-017-3835-6. (PMID: 10.1007/s10517-017-3835-6) ; Takatsu K. Interleukin 5 and B cell differentiation. Cytokine Growth Factor Rev. 1998;9(1):25-35. doi: https://doi.org/10.1016/s1359-6101(97)00034-8. (PMID: 10.1016/s1359-6101(97)00034-8) ; Nakanishi K. Unique action of interleukin-18 on T cells and other immune cells. Front. Immunol. 2018;9:763. doi: https://doi.org/10.3389/fimmu.2018.00763. (PMID: 10.3389/fimmu.2018.00763) ; Read KA, Powell MD, McDonald PW, Oestreich KJ. IL-2, IL-7, and IL-15: multistage regulators of CD4(+) T helper cell differentiation. Exp. Hematol. 2016;44(9):799-808. doi: https://doi.org/10.1016/j.exphem.2016.06.003. 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Front. Immunol. 2017;8:405. doi: https://doi.org/10.3389/fimmu.2017.00405. (PMID: 10.3389/fimmu.2017.00405) ; Boyman O, Sprent J. The role of interleukin-2 during homeostasis and activation of the immune system. Nat. Rev. Immunol. 2012;12(3):180-190. doi: https://doi.org/10.1038/nri3156. (PMID: 10.1038/nri3156) Contributed Indexing: Keywords: breast cancer; chemotherapy; fragmented human DNA; lymph cytokines; surgical treatment Substance Nomenclature: 0 (Chemokines) ; 0 (Cytokines) ; 9007-49-2 (DNA) ; 207137-56-2 (Interleukin-4) ; 0 (Adjuvants, Immunologic) Entry Date(s): Date Created: 20221127 Date Completed: 20221221 Latest Revision: 20221221 Update Code: 20240513

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Correlation of Cytokine Content in the Lymph with the Morphological Parameters of the Mesenteric Lymph Nodes in Adjuvant Therapy of Experimental Breast Cancer with the Use of Fragmented Human DNA.