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The importance of maintaining the remission of nonalcoholic fatty liver disease (NAFLD) has been overlooked. Here we aimed to clarify factors causing NAFLD recurrence. In this retrospective cohort study over 10.8 ± 5.4 years, we investigated 1260 male health check-up participants diagnosed with NAFLD who achieved remission. The data were compared between the maintained remission and recurrence group. Among all participants, 618 (49.0%) showed NAFLD recurrence at the last visit. Participants in the maintained remission group continued to lose weight (72.7 ± 9.1, 68.7 ± 8.5 and 68.2 ± 8.9 kg), whereas those in the recurrence group lost and regained weight (72.9 ± 9.9, 69.7 ± 9.3 and 73.0 ± 10.4 kg). Receiver operating characteristic curve analysis showed a weight regain of + 1.5 kg as the cutoff value for recurrence. The proportion of regular exercisers at the last visit was 34.6% in the maintained remission group and 24.5% in the recurrence group (p < 0.0001). Multivariable analysis revealed the amount of weight regain (in 1 kg increments; adjusted odds ratio, 1.29; 95% confidence interval, 1.24-1.34) and regular exercise at the last visit (adjusted odds ratio, 0.67; 95% confidence interval, 0.55-0.89) were independently associated with recurrence. These findings demonstrate a weight regain of 1.5 kg or more and lack of exercise were associated with NAFLD recurrence.

Titel:	A weight regain of 1.5 kg or more and lack of exercise are associated with nonalcoholic fatty liver disease recurrence in men.
Autor/in / Beteiligte Person:	Nakanishi, N ; Hashimoto, Y ; Okamura, T ; Ohbora, A ; Kojima, T ; Hamaguchi, M ; Fukui, M
Zeitschrift:	Scientific reports, Jg. 11 (2021-10-07), Heft 1, S. 19992
Veröffentlichung:	London : Nature Publishing Group, copyright 2011-, 2021
Medientyp:	academicJournal
ISSN:	2045-2322 (electronic)
DOI:	10.1038/s41598-021-99036-y
Schlagwort:	Abdomen diagnostic imaging Adult Cohort Studies Humans Japan Male Middle Aged Retrospective Studies Risk Factors Ultrasonography Non-alcoholic Fatty Liver Disease etiology Recurrence Sedentary Behavior Weight Gain
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Sci Rep] 2021 Oct 07; Vol. 11 (1), pp. 19992. <i>Date of Electronic Publication: </i>2021 Oct 07. MeSH Terms: Recurrence* ; Sedentary Behavior* ; Weight Gain* ; Non-alcoholic Fatty Liver Disease / *etiology ; Abdomen / diagnostic imaging ; Adult ; Cohort Studies ; Humans ; Japan ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors ; Ultrasonography References: JAMA Intern Med. 2019 Sep 1;179(9):1262-1271. (PMID: 31260026) ; Obes Rev. 2000 May;1(1):47-56. (PMID: 12119645) ; N Engl J Med. 2011 Jun 23;364(25):2392-404. (PMID: 21696306) ; Hepatology. 2016 Jul;64(1):73-84. (PMID: 26707365) ; Diabetes Care. 2012 Apr;35(4):873-8. (PMID: 22374640) ; Curr Pharm Des. 2020;26(32):3915-3927. (PMID: 32303161) ; Diabetes Care. 2015 Sep;38(9):1673-9. (PMID: 26156527) ; Hepatology. 2010 Jan;51(1):121-9. (PMID: 19827166) ; Hepatology. 2012 Jun;55(6):2005-23. (PMID: 22488764) ; N Engl J Med. 2018 Aug 16;379(7):623-632. (PMID: 30110591) ; Hepatology. 2006 Jun;43(6):1317-25. (PMID: 16729309) ; Ann Intern Med. 2005 Nov 15;143(10):722-8. (PMID: 16287793) ; J Clin Biochem Nutr. 2018 May;62(3):242-246. (PMID: 29892163) ; BMJ. 2015 Apr 20;350:h1551. (PMID: 25896935) ; Am J Clin Nutr. 2001 Nov;74(5):579-84. (PMID: 11684524) ; Am J Physiol Gastrointest Liver Physiol. 2008 Mar;294(3):G619-26. (PMID: 18174272) ; Diabetologia. 2012 Apr;55(4):885-904. (PMID: 22278337) ; Hepatology. 2019 Oct;70(4):1457-1469. (PMID: 30924946) ; J Clin Invest. 2005 May;115(5):1139-42. (PMID: 15864343) ; Nat Rev Gastroenterol Hepatol. 2018 Jan;15(1):11-20. (PMID: 28930295) ; Clin Gastroenterol Hepatol. 2009 Oct;7(10):1104-12. (PMID: 19523535) ; Gastroenterology. 2015 Aug;149(2):367-78.e5; quiz e14-5. (PMID: 25865049) ; J Clin Med. 2020 Apr 28;9(5):. (PMID: 32354182) ; Transplantation. 2011 Mar 27;91(6):684-9. (PMID: 21248661) ; Hepatology. 2010 Jun;51(6):1972-8. (PMID: 20209604) ; J Physiol. 2009 Apr 15;587(Pt 8):1805-16. (PMID: 19237421) ; Am J Gastroenterol. 2021 Apr;116(4):733-740. (PMID: 33982943) ; BMJ. 2012 Jul 10;345:e4439. (PMID: 22782848) ; Am J Gastroenterol. 2010 Mar;105(3):613-20. (PMID: 20040915) ; Liver Int. 2020 Feb;40 Suppl 1:72-76. (PMID: 32077608) ; Sci Rep. 2020 Jan 16;10(1):481. (PMID: 31949229) ; Liver Int. 2016 Feb;36(2):275-83. (PMID: 26176710) ; JAMA Intern Med. 2017 Mar 1;177(3):335-342. (PMID: 28097313) ; World J Gastroenterol. 2014 Jul 14;20(26):8407-15. (PMID: 25024598) ; Int J Mol Sci. 2020 Aug 16;21(16):. (PMID: 32824337) ; Clin Liver Dis. 2016 May;20(2):339-50. (PMID: 27063273) ; Biopsychosoc Med. 2017 Jun 6;11:14. (PMID: 28592990) ; J Gastroenterol Hepatol. 2007 Jun;22(6):778-87. (PMID: 17565630) ; J Physiol. 2008 Sep 1;586(17):4241-9. (PMID: 18617560) ; Gut. 2012 Mar;61(3):409-15. (PMID: 21846782) ; World J Gastroenterol. 2007 Mar 14;13(10):1579-84. (PMID: 17461452) ; J Hepatol. 2012 Jul;57(1):157-66. (PMID: 22414768) ; Arch Intern Med. 2012 Jun 11;172(11):837-44. (PMID: 22688992) ; Am J Gastroenterol. 2007 Dec;102(12):2708-15. (PMID: 17894848) ; Circulation. 2005 Oct 25;112(17):2735-52. (PMID: 16157765) ; Am J Kidney Dis. 2009 Jun;53(6):982-92. (PMID: 19339088) ; Nature. 2019 Dec;576(7785):51-60. (PMID: 31802013) ; Nat Rev Endocrinol. 2019 May;15(5):274-287. (PMID: 30655624) Entry Date(s): Date Created: 20211008 Date Completed: 20220112 Latest Revision: 20220112 Update Code: 20240513 PubMed Central ID: PMC8497533

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A weight regain of 1.5 kg or more and lack of exercise are associated with nonalcoholic fatty liver disease recurrence in men.