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While the neurotoxic effects of heavy metals at even low levels have been well-studied, few studies have examined the cardiovascular effects of heavy metals on resting heart rate and these have focused on adult populations. The present study aimed to examine the association between low-level environmental lead and mercury exposure and resting heart rate in community adolescents. As part of the China Jintan Cohort Study, 532 adolescents aged 12 years (SD = 0.6) were tested for blood levels of lead (BLL) and mercury (BML) and resting heart rate (RHR). Generalized linear models were conducted to test the relationship between BLL and BML and RHR, controlling for children's sex, age, and socioeconomic status. Analyses were clustered at the preschool level when the children were recruited to adjust for standard error. The mean (SD) BLL and BML were 3.14 (SD = 1.19) μg/dL and 1.26 (SD = 0.68) μg/L at age 12 years, respectively. After adjusting for confounders, we found a significant interaction between BML and BLL in predicting RHR in boys (B = -1.27, SE = 0.49, p < 0.01, n = 289). We created BLL and BML groups in boys based on median cut-offs. Boys in the High BLL/High BML group had significantly lower RHR (mean = 84.22 beats per minute [bpm], SD = 8.77, n = 61) than boys in the Low BLL/Low BML group (mean = 89.03 bpm, SD = 10.75, n = 69; p < 0.05). BML and BLL did not interact to predict RHR in girls (B = -0.18, SE = 0.88, p > 0.05, n = 242). Combined high BLL and BML were associated with low RHR in community adolescent boys. Low RHR is an indication of chronic under-arousal and has been implicated in psychopathology, particularly for externalizing behavior. Our findings may stimulate further communication and research in this area.

Titel:	Blood lead and mercury levels are associated with low resting heart rate in community adolescent boys.
Autor/in / Beteiligte Person:	Liu, J ; Portnoy, J ; Um, P ; Cui, N ; Rudo-Hutt, A ; Yan, C ; Raine, A ; Chen, A
Zeitschrift:	International journal of hygiene and environmental health, Jg. 233 (2021-04-01), S. 113685
Veröffentlichung:	Jena, Germany : Urban & Fischer, c2000-, 2021
Medientyp:	academicJournal
ISSN:	1618-131X (electronic)
DOI:	10.1016/j.ijheh.2020.113685
Schlagwort:	Adolescent Adult Child Child, Preschool China Cohort Studies Female Heart Rate Humans Male Lead Mercury
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, N.I.H., Extramural Language: English [Int J Hyg Environ Health] 2021 Apr; Vol. 233, pp. 113685. <i>Date of Electronic Publication: </i>2021 Feb 05. MeSH Terms: Lead* ; Mercury* ; Adolescent ; Adult ; Child ; Child, Preschool ; China ; Cohort Studies ; Female ; Heart Rate ; Humans ; Male References: PLoS One. 2013 May 29;8(5):e65230. (PMID: 23734241) ; J Am Acad Child Adolesc Psychiatry. 2004 Feb;43(2):154-62. (PMID: 14726721) ; Int Arch Occup Environ Health. 2005 Apr;78(3):243-7. (PMID: 15754204) ; J Am Acad Child Adolesc Psychiatry. 1997 Oct;36(10):1457-64. (PMID: 9334560) ; N Engl J Med. 2011 Mar 24;364(12):1116-25. (PMID: 21428767) ; Neurotoxicol Teratol. 2011 Mar-Apr;33(2):212-9. (PMID: 20934510) ; Tohoku J Exp Med. 2002 Dec;198(4):215-21. (PMID: 12630553) ; Neurotoxicology. 2012 Oct;33(5):1067-74. (PMID: 23227484) ; Endocrinology. 2015 Oct;156(10):3408-15. 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(PMID: 16781863) Grant Information: K01 ES015877 United States ES NIEHS NIH HHS; R01 ES018858 United States ES NIEHS NIH HHS; K02 ES019878 United States ES NIEHS NIH HHS; R01 HD087485 United States HD NICHD NIH HHS; P30 ES013508 United States ES NIEHS NIH HHS Contributed Indexing: Keywords: Autonomic function; Cardiovascular; Heavy metal; Lead; Mercury; Resting heart rate Substance Nomenclature: 2P299V784P (Lead) ; FXS1BY2PGL (Mercury) Entry Date(s): Date Created: 20210208 Date Completed: 20211025 Latest Revision: 20220402 Update Code: 20231215 PubMed Central ID: PMC7965295

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Blood lead and mercury levels are associated with low resting heart rate in community adolescent boys.