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CD206, a mannose receptor, is mainly expressed on the surface of alternatively activated macrophages where it acts as a pattern recognition receptor and plays a role in innate and adaptive immunity. This study investigated serum soluble CD206 (sCD206) levels in community-acquired pneumonia (CAP) and examined their clinical significance. sCD206 concentrations were measured in the sera of two independent cohorts with CAP (127 and 125 patients, respectively) and 42 controls. The expression of CD206 in the lung from autopsied cases was also examined. Patients with CAP showed significantly elevated sCD206 levels than did the controls (p < 0.0001). Notably, fatal CAP patients had more than two-fold higher sCD206 concentrations than survivors in both cohorts (p < 0.0001). Serum sCD206 concentrations were associated with Pneumonia Severity Index (PSI) and CURB-65 values. Importantly, even fatal CAP patients classified as PSI I-IV, CURB65 0-2 or age <75 years had comparatively higher levels of sCD206 than those classified as PSI V, CURB-65 3-5 or age ≥75 years. Immunohistochemically, the infiltration of CD206 + macrophages was found in the lungs of fatal cases. Elevated levels of sCD206 are associated with CAP prognosis, suggesting sCD206 might be a potential biomarker to predict severity for CAP.

Titel:	Macrophage Mannose Receptor CD206 Predicts Prognosis in Community-acquired Pneumonia.
Autor/in / Beteiligte Person:	Tsuchiya, K ; Suzuki, Y ; Yoshimura, K ; Yasui, H ; Karayama, M ; Hozumi, H ; Furuhashi, K ; Enomoto, N ; Fujisawa, T ; Nakamura, Y ; Inui, N ; Yokomura, K ; Suda, T
Zeitschrift:	Scientific reports, Jg. 9 (2019-12-10), Heft 1, S. 18750
Veröffentlichung:	London : Nature Publishing Group, copyright 2011-, 2019
Medientyp:	academicJournal
ISSN:	2045-2322 (electronic)
DOI:	10.1038/s41598-019-55289-2
Schlagwort:	Adult Aged Aged, 80 and over Biomarkers blood Case-Control Studies Community-Acquired Infections blood Community-Acquired Infections diagnosis Female Humans Japan epidemiology Kaplan-Meier Estimate Male Membrane Glycoproteins metabolism Middle Aged Pneumonia blood Pneumonia diagnosis Prospective Studies Receptors, Immunologic metabolism Severity of Illness Index Young Adult Community-Acquired Infections mortality Macrophages metabolism Membrane Glycoproteins blood Pneumonia mortality Receptors, Immunologic blood
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Sci Rep] 2019 Dec 10; Vol. 9 (1), pp. 18750. <i>Date of Electronic Publication: </i>2019 Dec 10. MeSH Terms: Community-Acquired Infections / mortality ; Macrophages / metabolism ; Membrane Glycoproteins / blood ; Pneumonia / mortality ; Receptors, Immunologic / *blood ; Adult ; Aged ; Aged, 80 and over ; Biomarkers / blood ; Case-Control Studies ; Community-Acquired Infections / blood ; Community-Acquired Infections / diagnosis ; Female ; Humans ; Japan / epidemiology ; Kaplan-Meier Estimate ; Male ; Membrane Glycoproteins / metabolism ; Middle Aged ; Pneumonia / blood ; Pneumonia / diagnosis ; Prospective Studies ; Receptors, Immunologic / metabolism ; Severity of Illness Index ; Young Adult Comments: Erratum in: Sci Rep. 2020 Feb 19;10(1):3324. (PMID: 32075990) References: Lung Cancer. 2010 Mar;67(3):361-5. (PMID: 19487045) ; Clin Infect Dis. 2007 Mar 1;44 Suppl 2:S27-72. (PMID: 17278083) ; Thorax. 2003 May;58(5):377-82. (PMID: 12728155) ; Infect Dis (Lond). 2015 Apr;47(4):203-8. (PMID: 25650730) ; Nat Rev Immunol. 2014 Feb;14(2):81-93. (PMID: 24445666) ; Immunity. 2010 May 28;32(5):593-604. (PMID: 20510870) ; J Leukoc Biol. 2012 Dec;92(6):1177-86. (PMID: 22966131) ; J Infect. 2016 Oct;73(4):375-7. (PMID: 27422701) ; J Cytol Mol Biol. 2014 Jan 10;1(1):. (PMID: 24672807) ; Infect Immun. 2008 Jun;76(6):2362-7. (PMID: 18391001) ; PLoS One. 2014 Mar 17;9(3):e92331. (PMID: 24637679) ; Am J Pathol. 2015 Jan;185(1):162-71. (PMID: 25447055) ; J Biol Chem. 2005 Sep 23;280(38):32811-20. (PMID: 15983039) ; Clin Vaccine Immunol. 2012 Mar;19(3):436-42. (PMID: 22219312) ; J Am Geriatr Soc. 2006 Aug;54(8):1212-9. (PMID: 16913987) ; N Engl J Med. 1997 Jan 23;336(4):243-50. (PMID: 8995086) ; Ann Am Thorac Soc. 2017 Jan;14(1):57-64. (PMID: 27684274) ; Arthritis Res Ther. 2017 Jan 19;19(1):9. (PMID: 28103926) ; Am J Respir Crit Care Med. 2005 Feb 15;171(4):388-416. (PMID: 15699079) ; Front Immunol. 2014 Oct 10;5:500. (PMID: 25346736) ; J Biol Chem. 2002 Nov 1;277(44):41613-23. (PMID: 12196537) ; Nat Rev Immunol. 2009 Jul;9(7):465-79. (PMID: 19521399) ; Nat Rev Immunol. 2003 Jan;3(1):23-35. (PMID: 12511873) ; J Allergy Clin Immunol. 2018 Jan;141(1):350-364.e8. (PMID: 28629744) ; PLoS One. 2012;7(5):e37393. (PMID: 22693573) ; Eur Respir Rev. 2015 Sep;24(137):505-9. (PMID: 26324812) ; Rheumatology (Oxford). 2019 Dec 1;58(12):2143-2152. (PMID: 31143953) ; Clin Chem Lab Med. 2014 Mar;52(3):453-61. (PMID: 24114918) ; Thorax. 2010 Nov;65(11):971-7. (PMID: 20965934) ; Nat Rev Immunol. 2013 Sep;13(9):621-34. (PMID: 23928573) ; Sci Rep. 2018 Sep 3;8(1):13129. (PMID: 30177769) ; J Infect. 2011 Sep;63(3):215-22. (PMID: 21784100) ; Clin Microbiol Infect. 2009 Sep;15(9):858-64. (PMID: 19702590) ; J Biol Chem. 2011 Mar 11;286(10):7822-9. (PMID: 21205820) Substance Nomenclature: 0 (Biomarkers) ; 0 (MRC1 protein, human) ; 0 (Membrane Glycoproteins) ; 0 (Receptors, Immunologic) Entry Date(s): Date Created: 20191212 Date Completed: 20201111 Latest Revision: 20210110 Update Code: 20240513 PubMed Central ID: PMC6904766

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Macrophage Mannose Receptor CD206 Predicts Prognosis in Community-acquired Pneumonia.