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Background: Serum bilirubin levels are inversely associated with obesity in adults. We are interested in whether neonatal jaundice is associated with childhood obesity in preterm infants.

Methods: Data were obtained from the US Collaborative Perinatal Project. Neonatal bilirubin levels were used as exposure factors for obesity at age 7 years. Logistic regression models were used to control for potential confounders and calculate odds ratios (ORs). A generalized estimating equation (GEE) model was used to correct for intracluster correlation coefficient. SAS was used for all statistical analyses.

Results: In the study subjects, 865 of 5019 preterm infants were obese at age 7 years. While neonatal total serum bilirubin (TSB) rose 1 mg/dl, body mass index (BMI) increased 0.03 kg/m 2 (95% confidence interval (CI) 0.02, 0.04). Compared with infants with TSB <3 mg/dl, the ORs (95% CIs) for obesity in infants with 3 mg/dl≤ TSB <6 mg/dl, 6 mg/dl≤ TSB <9 mg/dl, 9 mg/dl≤ TSB <12 mg/dl and TSB ≥12 mg/dl were, respectively, 1.18 (0.87, 1.59), 1.25 (0.93, 1.67), 1.52 (1.11, 2.09), and 1.67 (1.22, 2.07). By using subtypes of bilirubin as exposure factors and the GEE model to correct for intracluster correlation coefficient, similar trends of associations were observed.

Conclusion: Neonatal bilirubin levels have positive trends of associations with childhood obesity in preterm infants.

Titel:	Association between neonatal serum bilirubin and childhood obesity in preterm infants.
Autor/in / Beteiligte Person:	Luo, L ; Zou, L ; Dong, W ; He, Y ; Yu, H ; Lei, X
Zeitschrift:	Pediatric research, Jg. 86 (2019-08-01), Heft 2, S. 227-233
Veröffentlichung:	2012- : New York : Nature Publishing Group ; <i>Original Publication</i>: Basel ; New York : Karger., 2019
Medientyp:	academicJournal
ISSN:	1530-0447 (electronic)
DOI:	10.1038/s41390-019-0399-3
Schlagwort:	Adult Algorithms Body Mass Index Child Female Humans Hyperbilirubinemia blood Hyperbilirubinemia complications Infant, Newborn Infant, Premature Infant, Premature, Diseases Jaundice, Neonatal complications Male Mothers Neonatal Screening Odds Ratio Pediatric Obesity complications Prospective Studies Surveys and Questionnaires Young Adult Bilirubin blood Jaundice, Neonatal blood Pediatric Obesity blood
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Pediatr Res] 2019 Aug; Vol. 86 (2), pp. 227-233. <i>Date of Electronic Publication: </i>2019 Apr 17. MeSH Terms: Bilirubin / blood ; Jaundice, Neonatal / blood ; Pediatric Obesity / *blood ; Adult ; Algorithms ; Body Mass Index ; Child ; Female ; Humans ; Hyperbilirubinemia / blood ; Hyperbilirubinemia / complications ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases ; Jaundice, Neonatal / complications ; Male ; Mothers ; Neonatal Screening ; Odds Ratio ; Pediatric Obesity / complications ; Prospective Studies ; Surveys and Questionnaires ; Young Adult References: World Cancer Research Fund. American Institute for Cancer Research Policy and Action for Cancer Prevention. 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Association between neonatal serum bilirubin and childhood obesity in preterm infants.