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Natural killer (NK) cells are present in large populations at the maternal-fetal interface during early pregnancy. However, the role of NK cells in fetal growth is unclear. Here, we have identified a CD49a + Eomes + subset of NK cells that secreted growth-promoting factors (GPFs), including pleiotrophin and osteoglycin, in both humans and mice. The crosstalk between HLA-G and ILT2 served as a stimulus for GPF-secreting function of this NK cell subset. Decreases in this GPF-secreting NK cell subset impaired fetal development, resulting in fetal growth restriction. The transcription factor Nfil3, but not T-bet, affected the function and the number of this decidual NK cell subset. Adoptive transfer of induced CD49a + Eomes + NK cells reversed impaired fetal growth and rebuilt an appropriate local microenvironment. These findings reveal properties of NK cells in promoting fetal growth. In addition, this research proposes approaches for therapeutic administration of NK cells in order to reverse restricted nourishments within the uterine microenvironment during early pregnancy.

Titel:	Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors.
Autor/in / Beteiligte Person:	Fu, B ; Zhou, Y ; Ni, X ; Tong, X ; Xu, X ; Dong, Z ; Sun, R ; Tian, Z ; Wei, H
Link:	Volltextverfügbarkeit prüfen (via ScienceDirect)
Zeitschrift:	Immunity, Jg. 47 (2017-12-19), Heft 6, S. 1100-1113.e6
Veröffentlichung:	Cambridge, MA : Cell Press ; <i>Original Publication</i>: Cambridge, Mass. : Cell Press, c1994-, 2017
Medientyp:	academicJournal
ISSN:	1097-4180 (electronic)
DOI:	10.1016/j.immuni.2017.11.018
Schlagwort:	Abortion, Habitual genetics Abortion, Habitual pathology Adult Animals Antigens, CD genetics Antigens, CD immunology Basic-Leucine Zipper Transcription Factors genetics Basic-Leucine Zipper Transcription Factors immunology Carrier Proteins genetics Carrier Proteins immunology Cellular Microenvironment Cytokines genetics Cytokines immunology Decidua immunology Decidua pathology Female Fetal Growth Retardation genetics Fetal Growth Retardation immunology Fetal Growth Retardation pathology Fetus Gene Expression Regulation, Developmental HLA-G Antigens genetics HLA-G Antigens immunology Humans Integrin alpha1 genetics Integrin alpha1 immunology Intercellular Signaling Peptides and Proteins genetics Intercellular Signaling Peptides and Proteins immunology Killer Cells, Natural cytology Killer Cells, Natural immunology Leukocyte Immunoglobulin-like Receptor B1 genetics Leukocyte Immunoglobulin-like Receptor B1 immunology Mice Mice, Inbred C57BL Pregnancy Signal Transduction T-Box Domain Proteins genetics T-Box Domain Proteins immunology Abortion, Habitual immunology Adoptive Transfer Carrier Proteins metabolism Cytokines metabolism Fetal Development immunology Fetal Growth Retardation prevention & control Intercellular Signaling Peptides and Proteins metabolism Killer Cells, Natural transplantation
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Immunity] 2017 Dec 19; Vol. 47 (6), pp. 1100-1113.e6. MeSH Terms: Adoptive Transfer* ; Abortion, Habitual / immunology ; Carrier Proteins / metabolism ; Cytokines / metabolism ; Fetal Development / immunology ; Fetal Growth Retardation / prevention & control ; Intercellular Signaling Peptides and Proteins / metabolism ; Killer Cells, Natural / *transplantation ; Abortion, Habitual / genetics ; Abortion, Habitual / pathology ; Adult ; Animals ; Antigens, CD / genetics ; Antigens, CD / immunology ; Basic-Leucine Zipper Transcription Factors / genetics ; Basic-Leucine Zipper Transcription Factors / immunology ; Carrier Proteins / genetics ; Carrier Proteins / immunology ; Cellular Microenvironment ; Cytokines / genetics ; Cytokines / immunology ; Decidua / immunology ; Decidua / pathology ; Female ; Fetal Growth Retardation / genetics ; Fetal Growth Retardation / immunology ; Fetal Growth Retardation / pathology ; Fetus ; Gene Expression Regulation, Developmental ; HLA-G Antigens / genetics ; HLA-G Antigens / immunology ; Humans ; Integrin alpha1 / genetics ; Integrin alpha1 / immunology ; Intercellular Signaling Peptides and Proteins / genetics ; Intercellular Signaling Peptides and Proteins / immunology ; Killer Cells, Natural / cytology ; Killer Cells, Natural / immunology ; Leukocyte Immunoglobulin-like Receptor B1 / genetics ; Leukocyte Immunoglobulin-like Receptor B1 / immunology ; Mice ; Mice, Inbred C57BL ; Pregnancy ; Signal Transduction ; T-Box Domain Proteins / genetics ; T-Box Domain Proteins / immunology Comments: Comment in: Cell Mol Immunol. 2018 Nov;15(11):941-943. (PMID: 29572543) Contributed Indexing: Keywords: aged pregnancy; decidual NK cells; fetal development; fetal growth restriction; growth-promoting factors; maternal-fetal interface; tissue-resident NK Substance Nomenclature: 0 (Antigens, CD) ; 0 (Basic-Leucine Zipper Transcription Factors) ; 0 (Carrier Proteins) ; 0 (Cytokines) ; 0 (EOMES protein, human) ; 0 (HLA-G Antigens) ; 0 (Integrin alpha1) ; 0 (Intercellular Signaling Peptides and Proteins) ; 0 (LILRB1 protein, human) ; 0 (Leukocyte Immunoglobulin-like Receptor B1) ; 0 (NFIL3 protein, human) ; 0 (OGN protein, human) ; 0 (T-Box Domain Proteins) ; 0 (T-box transcription factor TBX21) ; 134034-50-7 (pleiotrophin) Entry Date(s): Date Created: 20171221 Date Completed: 20171226 Latest Revision: 20181202 Update Code: 20231215

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Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors.