Einzeltreffer — DigiBib

Objectives: This study sought to evaluate the prognostic significance of left ventricular late gadolinium enhancement (LV-LGE) incidentally found in atrial fibrillation (AF) patients who undergo ablation therapy.

Background: LV-LGE provides prognostic information in patients with ischemic and nonischemic cardiomyopathies. However, data on the clinical significance of incidental LV-LGE in the AF population are limited.

Methods: A total of 778 patients who were referred for radiofrequency ablation of AF underwent cardiac magnetic resonance examinations between June 2006 and January 2013. Patients with a history of myocardial infarction or ablation therapy were excluded. The presence of LV-LGE was assessed by experienced imaging physicians. Patients were followed for arrhythmia recurrence after the radiofrequency ablation procedure.

Results: Of 598 patients included in the study, 60% were men with a mean age of 64 years and a median AF duration of 25 months. LV-LGE was detected in 39 patients (6.5%). There were 240 arrhythmia recurrences observed involving 40% of patients over a median follow-up period of 52 months. On univariate analysis, age (hazard ratio [HR]: 1.02; 95% confidence interval [CI]: 1.00 to 1.03), male sex (HR: 0.63; 95% CI: 0.47 to 0.86), diabetes (HR: 1.53; 95% CI: 1.03 to 2.27), CHADS2 score (HR: 1.19; 95% CI: 1.04 to 1.36), CHA2DS2-VASc score (HR: 1.18; 95% CI: 1.08 to 1.30), left atrial (LA) fibrosis (HR: 1.66; 95% CI: 1.41 to 1.96), LV-LGE (HR: 1.83; 95% CI: 1.11 to 3.03), persistent AF (HR: 1.52; 95% CI: 1.11 to 2.09), and LA area (HR: 1.03; 95% CI: 1.01 to 1.05) were significantly associated with arrhythmia recurrence. The recurrence rate was 69% in patients with LV-LGE compared with 38% in patients without LV-LGE (p < 0.001). In a multivariate model, LA fibrosis and LV-LGE were independent predictors of arrhythmia recurrence.

Conclusions: In AF patients without history of myocardial infarction, LV-LGE is a significant independent predictor of arrhythmia recurrence after ablation therapy.

Titel:	Incidental LV LGE on CMR Imaging in Atrial Fibrillation Predicts Recurrence After Ablation Therapy.
Autor/in / Beteiligte Person:	Suksaranjit, P ; Akoum, N ; Kholmovski, EG ; Stoddard, GJ ; Chang, L ; Damal, K ; Velagapudi, K ; Rassa, A ; Bieging, E ; Challa, S ; Haider, I ; Marrouche, NF ; McGann, CJ ; Wilson, BD
Zeitschrift:	JACC. Cardiovascular imaging, Jg. 8 (2015-07-01), Heft 7, S. 793-800
Veröffentlichung:	New York : Elsevier, 2015
Medientyp:	academicJournal
ISSN:	1876-7591 (electronic)
DOI:	10.1016/j.jcmg.2015.03.008
Schlagwort:	Aged Atrial Fibrillation pathology Female Forecasting Gadolinium Humans Male Middle Aged Prognosis Recurrence Atrial Fibrillation surgery Catheter Ablation Magnetic Resonance Imaging Ventricular Function physiology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [JACC Cardiovasc Imaging] 2015 Jul; Vol. 8 (7), pp. 793-800. <i>Date of Electronic Publication: </i>2015 Jun 17. MeSH Terms: Catheter Ablation* ; Magnetic Resonance Imaging* ; Atrial Fibrillation / surgery ; Ventricular Function / physiology ; Aged ; Atrial Fibrillation / pathology ; Female ; Forecasting ; Gadolinium ; Humans ; Male ; Middle Aged ; Prognosis ; Recurrence Comments: Comment in: JACC Cardiovasc Imaging. 2015 Jul;8(7):801-3. (PMID: 26183553) Contributed Indexing: Keywords: ablation therapy; atrial fibrillation; cardiac magnetic resonance; late gadolinium enhancement Substance Nomenclature: AU0V1LM3JT (Gadolinium) Entry Date(s): Date Created: 20150622 Date Completed: 20160509 Latest Revision: 20160518 Update Code: 20240513

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.

Incidental LV LGE on CMR Imaging in Atrial Fibrillation Predicts Recurrence After Ablation Therapy.