[Effect of ropivacaine combined with pancuronium on neuromuscular transmission and effectiveness of neostigmine and 4-aminopyridine for blockade reversal: experimental study].

Braga Ade, F ; Carvalho, VH ; et al.

In: Revista brasileira de anestesiologia, Jg. 65 (2015-03-01), Heft 2, S. 136-40

academicJournal

Background and Objectives: The local anesthetic effects on neuromuscular junction and its influence on blockade produced by nondepolarizing neuromuscular blockers are still under-investigated; however, this interaction has been described in experimental studies and in humans. The aim of this study was to evaluate in vitro the interaction between ropivacaine and pancuronium, the influence on transmission and neuromuscular blockade, and the effectiveness of neostigmine and 4-aminopyridine to reverse the blockade.

Methods: Rats were divided into groups (n=5) according to the study drug: ropivacaine (5μgmL(-1)); pancuronium (2μg.mL(-1)); ropivacaine+pancuronium. Neostigmine and 4-aminopyridine were used at concentrations of 2μgmL(-1) and 20μgmL(-1), respectively. The effects of ropivacaine on membrane potential and miniature end-plate potential, the amplitude of diaphragm responses before and 60minutes after the addition of ropivacaine (degree of neuromuscular blockade with pancuronium and with the association of pancuronium-ropivacaine), and the effectiveness of neostigmine and 4-aminopyridine on neuromuscular block reversal were evaluated.

Results: Ropivacaine did not alter the amplitude of muscle response (the membrane potential), but decreased the frequency and amplitude of the miniature end-plate potential. Pancuronium blockade was potentiated by ropivacaine, and partially and fully reversed by neostigmine and 4-aminopyridine, respectively.

Conclusions: Ropivacaine increased the neuromuscular block produced by pancuronium. The complete antagonism with 4-aminopyridine suggests presynaptic action of ropivacaine.

Titel:	[Effect of ropivacaine combined with pancuronium on neuromuscular transmission and effectiveness of neostigmine and 4-aminopyridine for blockade reversal: experimental study].
Autor/in / Beteiligte Person:	Braga Ade, F ; Carvalho, VH ; Braga, FS ; Potério, GM ; Santos, FN
Zeitschrift:	Revista brasileira de anestesiologia, Jg. 65 (2015-03-01), Heft 2, S. 136-40
Veröffentlichung:	[Rio de Janeiro, Brazil] : Elsevier Editora Ltda. em nome de Sociedade Brasileira de Anestesiologia ; <i>Original Publication</i>: Rio de Janeiro : Sociedade Brasileira de Anestesiologia, 2015
Medientyp:	academicJournal
ISSN:	1806-907X (electronic)
DOI:	10.1016/j.bjan.2013.10.020
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: Portuguese Transliterated Title: Efeito da associação ropivacaina-pancurônio na transmissão neuromuscular e eficácia da neostigmine e 4-aminopiridina na reversão do bloqueio: estudo experimental. Publication Type: English Abstract; Journal Article Language: Portuguese [Rev Bras Anestesiol] 2015 Mar-Apr; Vol. 65 (2), pp. 136-40. <i>Date of Electronic Publication: </i>2014 Nov 08. Contributed Indexing: Keywords: Anestésicos Locais, Ropivacaina; Animais, Ratos; Animals, rats; Bloqueadores neuromusculares; Local anesthetics, ropivacaine; Neuromuscular blockers; Nondepolarising, pancuronium; Não despolarizantes, Pancurônio Entry Date(s): Date Created: 20150211 Date Completed: 20150210 Latest Revision: 20150210 Update Code: 20240513

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