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The increasing prevalence of diabetes especially type 2 diabetes worldwide is indisputable. Diabetics suffer increased morbidity and mortality, compared to their non-diabetic counterparts, not only because of vascular complications, but also because of an increased fracture incidence. Both types 1 and 2 diabetes and some medications used to treat it are associated with osteoporotic fractures. The responsible mechanisms remain incompletely elucidated. In this review, we evaluate the role of glycemic control in bone health, and the effect of anti-diabetic medications such as thiazolidinediones, sulfonylureas, DPP-4 inhibitors, and GLP-1 agonists. In addition, we examine the possible role of insulin and metformin as anabolic agents for bone. Lastly, we identify the current and future screening tools that help evaluate bone health in diabetics and their limitations. In this way we can offer individualized treatment, to the at-risk diabetic population.

Titel:	Diabetes and bone health.
Autor/in / Beteiligte Person:	Antonopoulou, M ; Bahtiyar, G ; Banerji, MA ; Sacerdote, AS
Zeitschrift:	Maturitas, Jg. 76 (2013-11-01), Heft 3, S. 253-9
Veröffentlichung:	Limerick : Elsevier/North Holland Biomedical Press ; <i>Original Publication</i>: Amsterdam, Elsevier/North Holland Biomedical Press., 2013
Medientyp:	academicJournal
ISSN:	1873-4111 (electronic)
DOI:	10.1016/j.maturitas.2013.04.004
Schlagwort:	Bone Density drug effects Humans Insulin pharmacology Insulin therapeutic use Metformin pharmacology Metformin therapeutic use Osteoporosis prevention & control Osteoporotic Fractures prevention & control Bone and Bones drug effects Diabetes Complications prevention & control Diabetes Mellitus drug therapy Hypoglycemic Agents adverse effects Osteoporosis etiology Osteoporotic Fractures etiology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Review Language: English [Maturitas] 2013 Nov; Vol. 76 (3), pp. 253-9. <i>Date of Electronic Publication: </i>2013 Apr 28. MeSH Terms: Bone and Bones / drug effects ; Diabetes Complications / prevention & control ; Diabetes Mellitus / drug therapy ; Hypoglycemic Agents / adverse effects ; Osteoporosis / etiology ; Osteoporotic Fractures / etiology ; Bone Density / drug effects ; Humans ; Insulin / pharmacology ; Insulin / therapeutic use ; Metformin / pharmacology ; Metformin / therapeutic use ; Osteoporosis / prevention & control ; Osteoporotic Fractures / prevention & control Contributed Indexing: Keywords: AGEs; BMD; CAH; DM; DPP-4; DXA; Diabetes; FRAX; FSH; Fractures; GH; GIP; GLP; IGF-1; IGFBP3; LH; Osteoporosis; PCOS; PPAR-gamma agonists; PTH; SHBG; TZDs; Thiazolidinediones; advanced glycation endproducts; bone mineral density; congenital adrenal hyperplasia; diabetes mellitus; dipeptydil petptidase-4; dual-energy X-ray absorptiometry; follicle stimulating hormone; fracture risk assessment tool; gastric inhibitory polypeptide; glucagon like peptide; growth hormone; insulin like growth factor 1; insulin-like growth factor binding protein 3; luteinizing hormone; parathyroid hormone; peroxisome proliferator-activated receptor gamma; polycystic ovarian syndrome; sex hormone binding globulin; thiazolidinediones Substance Nomenclature: 0 (Hypoglycemic Agents) ; 0 (Insulin) ; 9100L32L2N (Metformin) Entry Date(s): Date Created: 20130501 Date Completed: 20140526 Latest Revision: 20220410 Update Code: 20240513

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Diabetes and bone health.