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Schizophrenia is a common and serious mental disorder, in which the majority of patients require long-term antipsychotic treatment. Several studies have suggested that schizophrenia is associated with decreased neurotrophins such as brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF). Investigation of the mechanisms of pharmacological agents that are used in the treatment of schizophrenia has been used to better understand the basis of the pathology associated with this mental illness. The present study aims to investigate the effect of chronic treatment with antipsychotics, named haloperidol (HAL), clozapine (CLO), olanzapine (OLZ) or aripiprazole (ARI) on BDNF and NGF levels in rat hippocampus. Adult male Wistar rats received daily injections of HAL (1.5 mg/kg), CLO (25 mg/kg), OLZ (2.5, 5 or 10 mg/kg) or ARI (2, 10 or 20 mg/kg), whereas control animals were given vehicle. BDNF and NGF levels were measured in rat hippocampus by sandwich-ELISA. The results showed that chronic administration of antipsychotics did not modify BDNF and NGF levels in rat hippocampus, suggesting that their therapeutic properties are not mediated by stimulation of these neurotrophins.

Titel:	Lack of effect of antipsychotics on BNDF and NGF levels in hippocampus of Wistar rats.
Autor/in / Beteiligte Person:	Valvassori, SS ; Stertz, L ; Andreazza, AC ; Rosa, MI ; Kapczinski, F ; Streck, EL ; Quevedo, J
Zeitschrift:	Metabolic brain disease, Jg. 23 (2008-06-01), Heft 2, S. 213-9
Veröffentlichung:	2005- : Amsterdam : Springer ; <i>Original Publication</i>: New York : Plenum, c1986-, 2008
Medientyp:	academicJournal
ISSN:	0885-7490 (print)
DOI:	10.1007/s11011-008-9083-8
Schlagwort:	Animals Antipsychotic Agents therapeutic use Aripiprazole Benzodiazepines pharmacology Benzodiazepines therapeutic use Brain-Derived Neurotrophic Factor metabolism Clozapine pharmacology Clozapine therapeutic use Drug Administration Schedule Haloperidol pharmacology Haloperidol therapeutic use Hippocampus metabolism Hippocampus physiopathology Male Nerve Growth Factor metabolism Olanzapine Piperazines pharmacology Piperazines therapeutic use Quinolones pharmacology Quinolones therapeutic use Rats Rats, Wistar Time Up-Regulation drug effects Up-Regulation physiology Antipsychotic Agents pharmacology Brain-Derived Neurotrophic Factor drug effects Hippocampus drug effects Nerve Growth Factor drug effects
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Metab Brain Dis] 2008 Jun; Vol. 23 (2), pp. 213-9. <i>Date of Electronic Publication: </i>2008 May 22. MeSH Terms: Antipsychotic Agents / pharmacology ; Brain-Derived Neurotrophic Factor / drug effects ; Hippocampus / drug effects ; Nerve Growth Factor / drug effects ; Animals ; Antipsychotic Agents / therapeutic use ; Aripiprazole ; Benzodiazepines / pharmacology ; Benzodiazepines / therapeutic use ; Brain-Derived Neurotrophic Factor / metabolism ; Clozapine / pharmacology ; Clozapine / therapeutic use ; Drug Administration Schedule ; Haloperidol / pharmacology ; Haloperidol / therapeutic use ; Hippocampus / metabolism ; Hippocampus / physiopathology ; Male ; Nerve Growth Factor / metabolism ; Olanzapine ; Piperazines / pharmacology ; Piperazines / therapeutic use ; Quinolones / pharmacology ; Quinolones / therapeutic use ; Rats ; Rats, Wistar ; Time ; Up-Regulation / drug effects ; Up-Regulation / physiology References: Arch Gen Psychiatry. 1998 Mar;55(3):225-32. (PMID: 9510216) ; J Psychiatr Res. 2007 Jan-Feb;41(1-2):31-5. (PMID: 16546213) ; Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11824-8. (PMID: 11553785) ; Arch Gen Psychiatry. 1995 Oct;52(10):805-18; discussion 819-20. (PMID: 7575100) ; Schizophr Res. 2001 Oct 1;52(1-2):79-86. (PMID: 11595394) ; Schizophr Res. 1999 May 25;37(2):201-3. (PMID: 10374657) ; Science. 1995 Oct 27;270(5236):593-8. (PMID: 7570017) ; Eur J Neurosci. 2001 Jul;14(1):135-44. (PMID: 11488957) ; Health Technol Assess. 2003;7(13):1-193. (PMID: 12925268) ; Am J Psychiatry. 1980 Oct;137(10):1163-72. (PMID: 6106389) ; Schizophr Res. 2007 Mar;91(1-3):1-5. (PMID: 17306505) ; J Neurosci Res. 2003 Jan 1;71(1):127-31. (PMID: 12478621) ; Nature. 1989 Sep 14;341(6238):149-52. (PMID: 2779653) ; Arch Gen Psychiatry. 1987 Jul;44(7):660-9. (PMID: 3606332) ; Neuroscience. 2003;121(4):825-8. (PMID: 14580931) ; J Neurosci. 2005 Jan 12;25(2):372-83. (PMID: 15647480) ; Naunyn Schmiedebergs Arch Pharmacol. 2007 Oct;376(1-2):127-33. (PMID: 17673979) ; Acta Psychiatr Scand. 1988 Apr;77(4):369-78. (PMID: 2898870) ; Basic Clin Pharmacol Toxicol. 2007 Nov;101(5):315-9. (PMID: 17910614) ; Mol Psychiatry. 2005 Apr;10(4):345-52. (PMID: 15655562) ; Proc Natl Acad Sci U S A. 1990 Jul;87(14):5454-8. (PMID: 2164684) ; Science. 2002 Mar 1;295(5560):1729-34. (PMID: 11872844) ; Life Sci. 2006 Jul 4;79(6):570-4. (PMID: 16513140) ; Neuropsychobiology. 1997;36(2):65-8. (PMID: 9267854) ; Eur Neuropsychopharmacol. 2001 Oct;11 Suppl 4:S391-6. (PMID: 11587886) ; J Psychiatry Neurosci. 2006 Jan;31(1):32-7. (PMID: 16496033) ; Mol Psychiatry. 2003 Feb;8(2):217-24. (PMID: 12610654) ; Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6711-5. (PMID: 8341689) ; J Mol Neurosci. 2000 Feb-Apr;14(1-2):27-37. (PMID: 10854034) ; Schizophr Bull. 1997;23(3):403-21. (PMID: 9327506) ; Arch Gen Psychiatry. 2005 Apr;62(4):361-70. (PMID: 15809403) ; J Neurosci Res. 2000 Jun 15;60(6):783-94. (PMID: 10861791) ; Learn Mem. 2003 Mar-Apr;10(2):86-98. (PMID: 12663747) ; Am J Psychiatry. 2005 Dec;162(12):2233-45. (PMID: 16330585) ; Neurosci Lett. 1992 Apr 13;138(1):153-6. (PMID: 1407655) ; Neurosci Lett. 2004 Nov 30;372(1-2):157-60. (PMID: 15531108) ; Pharmacol Biochem Behav. 2004 Aug;78(4):751-6. (PMID: 15301931) ; J Biol Chem. 1951 Nov;193(1):265-75. (PMID: 14907713) ; Schizophr Res. 2006 Feb 15;82(1):95-106. (PMID: 16442781) Substance Nomenclature: 0 (Antipsychotic Agents) ; 0 (Brain-Derived Neurotrophic Factor) ; 0 (Piperazines) ; 0 (Quinolones) ; 12794-10-4 (Benzodiazepines) ; 82VFR53I78 (Aripiprazole) ; 9061-61-4 (Nerve Growth Factor) ; J60AR2IKIC (Clozapine) ; J6292F8L3D (Haloperidol) ; N7U69T4SZR (Olanzapine) Entry Date(s): Date Created: 20080523 Date Completed: 20080828 Latest Revision: 20211020 Update Code: 20231215

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Lack of effect of antipsychotics on BNDF and NGF levels in hippocampus of Wistar rats.