Tight Coordination of Protein Translation and HSF1 Activation Supports the Anabolic Malignant State.
In: Science, Jg. 341 (2013-07-19), Heft 6143, S. 250-250
academicJournal
Zugriff:
The article discusses research in ribosome biogenesis, with a focus on the ribosome's translational activity and activation of HSF1, the heat-shock transcription factor. Topics include tumor growth and malignant states associated with anabolic demands, ribosome regulation and cancer incidence, and eukaryotic initiation factors (elFs). Additional information is presented on thioredoxin-interacting protein (TXNIP) messenger RNA (mRNA), glucose uptake and translational flux, and acute myeloid leukemia cells.
Titel: |
Tight Coordination of Protein Translation and HSF1 Activation Supports the Anabolic Malignant State.
|
---|---|
Autor/in / Beteiligte Person: | Santagata, Sandro ; Mendillo, Marc L. ; Tang, Yun-chi ; Subramanian, Aravind ; Perley, Casey C. ; Roche, Stéphane P. ; Wong, Bang ; Narayan, Rajiv ; Kwon, Hyoungtae ; Koeva, Martina ; Amon, Angelika ; Golub, Todd R. ; Porco Jr., John A. ; Whitesell, Luke ; Lindquist, Susan |
Zeitschrift: | Science, Jg. 341 (2013-07-19), Heft 6143, S. 250-250 |
Veröffentlichung: | 2013 |
Medientyp: | academicJournal |
ISSN: | 0036-8075 (print) |
DOI: | 10.1126/science.1238303 |
Schlagwort: |
|
Sonstiges: |
|