The Absorption of Cephalosporin on Vinyl Polymers to Form Antibacterial Surfaces.
In: Journal of Bioactive & Compatible Polymers, Jg. 16 (2001-07-01), Heft 4, S. 294-306
academicJournal
Zugriff:
In order to obtain antimicrobial polymer compositions potentially suitable for catheter fabrication, a cephalosporin was bonded to ethylene-vinyl alcohol copolymers and to their derivatives containing hydrophilic positively or negatively charged groups. The polymers were characterized by chemical and physico-chemical techniques. The antibiotic was adsorbed at a density of 1.3 mg/cm[SUP2] onto the unaffected polymer surface. The density was increased up to 1.78 mg/cm[SUP2] when the polymer was derivatized, The elution rate of the antibiotic from the surfaces and its antimicrobial activity were determined. The underivatized polymer has shown antimicrobial activity for 24 h whereas the carboxylated polymer was active for 72 h. During this time 32% of the antibiotic was eluted from the underivatized polymer and approximately 15% from the derivatized polymer. [ABSTRACT FROM AUTHOR]
Titel: |
The Absorption of Cephalosporin on Vinyl Polymers to Form Antibacterial Surfaces.
|
---|---|
Autor/in / Beteiligte Person: | Marconi, W. ; Monopoli, G. ; Piozzi, A. ; Di Rosa, R. |
Zeitschrift: | Journal of Bioactive & Compatible Polymers, Jg. 16 (2001-07-01), Heft 4, S. 294-306 |
Veröffentlichung: | 2001 |
Medientyp: | academicJournal |
ISSN: | 0883-9115 (print) |
DOI: | 10.1106/V3VU-TCWE-MP4E-WY8T |
Schlagwort: |
|
Sonstiges: |
|