Procena zahvaćenosti aksilarnih limfnih nodusa u zavisnosti od veličine tumora i histološkog i nuklearnog gradusa kod bolesnica sa karcinomom dojke.
In: Vojnosanitetski Pregled: Military Medical & Pharmaceutical Journal of Serbia, Jg. 69 (2012-05-01), Heft 5, S. 414-419
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Zugriff:
Background/Aim. There are a lot of studies aiding to the opinion that the involvement degree of axilla lymph nodes grows depending on increase of breast tumor size, and its histological and nuclear grades. The aim of this study was to assess the risk of axillary lymph nodes involvement, as well as the relation between the tumor size, histological and nuclear grades in a group of female patients who underwent breast cancer surgery, including levels 1-3 axillary dissection. Methods. Investigation covered 900 patients operated on during 2005-2008 who underwent modified radical mastectomy including axillar dissection. We assessed a number of involved lymph nodes, depending on tumor macroscopic size (T), histological grade (HG) and nuclear grade (NG). Results. A total number of examined lymph nodes was 9977. The incidence of involved lymph nodes was from 18.6% with T1 tumor size up to 60.2% with T4 tumor size. Concerning histological grade, the number of involved lymph nodes ranged from 14.2% (HGI) to 45.1% (HGIII); while in terms of nuclear grade, the number of involved lymph nodes ranged from 17.4% (NGI) to 54.5% (NGIV). By using X²-test for trend and odds ratio (OR), the results showed that the axillary lymph nodes involvement degree was increased with the increase of the tumor size and its histological and nuclear grades. The risk of axillary lymphatic nodes involvement was 1.43 times higher in the group of T2 tumors size compared to the smaller tumors T1 size, and even up to 6.62 times higher in case of T4 tumor size. It was also increased from 1.79 times for HGII to even 4.98 times for HGIII, and from 1.44 times for NGII to 5.71 times for NGIV. Conclusion. In breast cancer patients, there is a strong correlation between tumor size, its histological and nuclear grades and the risk of axillary lymph nodes involvement. [ABSTRACT FROM AUTHOR]
Uvod/Cilj. Postoji dosta studija koje govore u prilog tome da zahvaćenost limfnih nodusa aksile raste u zavisnosti od povećanja veličine tumora, odnosno histološkog i nuklearnog gradusa. Cilj ovog rada bio je da se proceni rizik od zahvatanja aksilarnih limfnih nodusa kao i veza između veličine tumora, histološkog i nuklearnog gradusa u grupi bolesnica operisanih od karcinoma dojke kod kojih je urađena kompletna disekcija aksile. Metode. Ispitivanjem je obuhvaćeno 900 bolesnica operisanih u periodu od 2005 do 2008. godine kod kojih je rađena modifikovana radikalna mastektomija sa disekcijom aksile. Procenjivan je broj zahvaćenih limfnih nodusa u zavisnosti od makroskopske veličine tumora (T), histološkog gradusa (HG) i nuklearnog gradusa (NG). Rezultati. Ukupan broj pregledanih limfnih nodusa bio je 9 977. Broj zahvaćenih limfnih nodusa kod T1 bio je 18,6%, dok je kod T4 bio 60,2%. Za histološki gradus broj zahvaćenih limfnih nodusa kretao se od 14,2% (HGI) do 45,1% (HGIII). S obzirom na nuklearni gradus broj zahvaćenih limfnih nodusa kretao se od 17,4% (NGI) do 54,5% (NGIV). Korišćenjem X²-testa za trend i odds ratio (OR), pokazano je da zahvaćenost aksilarnih limfnih nodusa raste sa povećanjem veličine tumora, odnosno histološkog i nuklearnog gradusa. Rizik od zahvatanja aksilarnih limfnih nodusa bio je 1,43 puta veči kod tumora veličine T2 u odnosu na najmanje tumore (veličina T1), a čak 6,62 puta veći ukoliko je tumor bio veličine T4. Takođe, rastao je od 1,79 puta kod HGII do čak 4,98 puta za HGIII i od 1,44 puta za NGII do 5,71 puta za NGIV. Zaključak. Potvrđeno je da porast veličine tumora, histološkog i nuklearnog gradusa povećava rizik od zahvatanja aksilarnih limfnih nodusa kod bolesnica sa karcinomom dojke. [ABSTRACT FROM AUTHOR]
Titel: |
Procena zahvaćenosti aksilarnih limfnih nodusa u zavisnosti od veličine tumora i histološkog i nuklearnog gradusa kod bolesnica sa karcinomom dojke.
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Autor/in / Beteiligte Person: | Bojić, Toplica ; Djordjević, Nebojša ; Karanikolić, Aleksandar ; Filipović, Sladjana ; Granić, Miroslav ; Poultsidi, Antigoni A. |
Zeitschrift: | Vojnosanitetski Pregled: Military Medical & Pharmaceutical Journal of Serbia, Jg. 69 (2012-05-01), Heft 5, S. 414-419 |
Veröffentlichung: | 2012 |
Medientyp: | academicJournal |
ISSN: | 0042-8450 (print) |
DOI: | 10.2298/VSP1205414B |
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