Detailed characterization of Redondovirus in saliva of SARS-CoV-2-infected individuals in Sao Paulo, Brazil.
In: PLoS ONE, Jg. 18 (2023-08-31), Heft 8, S. 1-10
academicJournal
Zugriff:
Background: Redondovirus (ReDoV) is a DNA virus present in the respiratory tract of many healthy individuals. Since SARS-CoV-2, the virus responsible for COVID-19, also primarily infects the same site, we evaluated whether ReDoV was present at increased frequency in patients with COVID-19 and influenced infection parameters. Methods: Saliva samples were collected weekly from 59 individuals with COVID-19 and from 132 controls. ReDoV was detected by polymerase chain reaction and the genotypes were identified by metagenomics. Torque Teno Virus (TTV) in these samples were previously reported. Results: ReDoV was detected in saliva more frequently from COVID-19 patients (72.9%) than from controls (50.0%) (p = 0.0015). There were no associations between ReDoV detection and either continuous or intermittent SARS-CoV-2 shedding, the duration of SARS-CoV-2 detection in saliva, patients' sex or if infection was by the B1 or Gamma strain. The two ReDoV strains, Brisavirus and Vientovirus, were present in equivalent frequencies in ReDoV-positive COVID-19 patients and controls. Phylogenetic analysis suggested that the two ReDoV strains in Brazil were similar to strains previously detected on other continents. Conclusion: ReDoV expression in saliva is increased in males and females in Brazil with mild COVID-19 but its presence does not appear to influence properties of the SARS-CoV-2 infection. [ABSTRACT FROM AUTHOR]
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Detailed characterization of Redondovirus in saliva of SARS-CoV-2-infected individuals in Sao Paulo, Brazil.
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Autor/in / Beteiligte Person: | Charlys da Costa, Antonio ; Mendes-Correa, Maria C. ; Tozetto-Mendoza, Tania Regina ; Villas-Boas, Lucy S. ; de Paula, Anderson Vicente ; Paiao, Heuder Gustavo Oliveira ; Leal, Fabio E. ; Ferreira, Noely E. ; Honorato, Layla ; Leal, Elcio ; Grandi, Giuliano ; dos Santos Morais, Vanessa ; Manuli, Erika R. ; Sabino, Ester C. ; Witkin, Steven S. |
Zeitschrift: | PLoS ONE, Jg. 18 (2023-08-31), Heft 8, S. 1-10 |
Veröffentlichung: | 2023 |
Medientyp: | academicJournal |
ISSN: | 1932-6203 (print) |
DOI: | 10.1371/journal.pone.0291027 |
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