Adult Onset Nocturnal Enuresis: Identifying Causes, Cofactors and Impact on Quality of Life.

Objectives: The objectives of the present study were: (i) Evaluate common co‐pathologies associated with, and potentially contributing to adult onset Nocturnal enuresis (NE) in a tertiary referral population; and (ii) quantify its impact on QoL with validated questionnaires. Methods: Following Institutional Review Board approval, patients with adult onset NE were reviewed with history, physical examination, urodynamic studies, questionnaires: Overactive bladder questionnaire short‐form (OAB‐qSF), Urogenital Distress Inventory (UDI‐6), AUA symptom score (AUA‐SS) and Patient Global Impression scale (PGIS). Results: Between 2004 and 2016, 45 NE patients (19 male, 26 female) were identified. Twenty‐five patients (56%) had an associated diagnosis of neurogenic bladder (NGB). Five (11%) reported no other LUTS or associated conditions. Forty (89%) had at least one of the following contributing factors: sedative use, OAB (bothersome symptoms based on UDI‐6), voiding dysfunction (also based on UDI‐6 or AUA‐SS), abnormal UDS finding, and/or confirmed obstructive sleep apnea (OSA). Overall, 20% had two contributing factors, and 31% each had three and four factors. Among all patients, 76% reported sedative use and of 36 patients with UDS, 75% had abnormal findings. Of the 41 questionnaire respondents, mean AUA‐SS among men was 22.5 (range 8–35) and mean UDI‐6 score among women was 9.3 (range 2–16). Mean PGI‐S score was 3.1 (range 1–4) and mean Health Related Quality of Life (HRQL) subscale, as part of the OAB‐q SF was 44 (range 22–78). Conclusions: Nocturnal enuresis is associated with multiple possible co‐factors in all populations with majority reporting use of sedating medications. NE is associated with significant symptom bother and impacts greatly on QoL. [ABSTRACT FROM AUTHOR]